System N-like transporters | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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SLC superfamily of solute carriers
SLC38 family of sodium-dependent neutral amino acid transporters
System N-like transporters

System N-like transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

1173

SNAT3 (Sodium-coupled neutral amino acid transporter 3 / SLC38A3) C Show summary »« Hide summary

SNAT5 (Sodium-coupled neutral amino acid transporter 5 / SLC38A5) C Show summary »« Hide summary

Target Id

1173

Nomenclature

Sodium-coupled neutral amino acid transporter 5

Systematic nomenclature

SLC38A5

Common abbreviation

SNAT5

Previous and unofficial names

SN2 | JM24 | amino acid transporter system N2 | solute carrier family 38, member 5 | solute carrier family 38

Genes

SLC38A5 (Hs), Slc38a5 (Mm), Slc38a5 (Rn)

Ensembl ID

ENSG00000017483 (Hs), ENSMUSG00000031170 (Mm), ENSRNOG00000027767 (Rn)

UniProtKB AC

Q8WUX1 (Hs), Q3U1J0 (Mm), A2VCW5 (Rn)

Bioparadigms SLC Tables

SLC38A5 (Hs)

RESOLUTE

SLC38A5 (Hs)

Substrates

L-asparagine, L-serine, L-histidine, L-glutamine > glycine, L-alanine [3]

Substrates

MeAIB

Labelled ligands

[¹⁴C]histidine

[³H]histidine

Stoichiometry

1 Na⁺ : 1 amino acid (in) : 1 H⁺ (out) [3]

References

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1. Bröer A, Albers A, Setiawan I, Edwards RH, Chaudhry FA, Lang F, Wagner CA, Bröer S. (2002) Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ions. J Physiol (Lond.), 539 (Pt 1): 3-14. [PMID:11850497]

2. Fei YJ, Sugawara M, Nakanishi T, Huang W, Wang H, Prasad PD, Leibach FH, Ganapathy V. (2000) Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter. J Biol Chem, 275 (31): 23707-17. [PMID:10823827]

3. Nakanishi T, Sugawara M, Huang W, Martindale RG, Leibach FH, Ganapathy ME, Prasad PD, Ganapathy V. (2001) Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N. Biochem Biophys Res Commun, 281 (5): 1343-8. [PMID:11243884]

How to cite this family page

Database page citation:

System N-like transporters. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=226.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.