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L-Tyrosine hydroxylase

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Target not currently curated in GtoImmuPdb

Target id: 1243

Nomenclature: L-Tyrosine hydroxylase

Family: Amino acid hydroxylases, Catecholamine turnover

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 528 11p15.5 TH tyrosine hydroxylase
Mouse - 498 7 88.06 cM Th tyrosine hydroxylase
Rat - 498 1q41 Th tyrosine hydroxylase
Previous and Unofficial Names Click here for help
Tyrosine 3-monooxygenase | The | tyrosine 3-hydroxylase
Database Links Click here for help
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.14.16.2 L-tyrosine + O2 -> levodopa
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
L-tyrosine Substrate is endogenous in the given species N/A - -
Products Click here for help
Product Species Reference
levodopa Product is produced endogenously in the given species None
Cofactors Click here for help
Cofactor Species Comments Reference
sapropterin Human
Fe2+ Human
Endogenous activators
Protein kinase A-mediated phosphorylation  [1]

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
methyltyrosine Small molecule or natural product Approved drug Primary target of this compound Hs Inhibition - -
α-propyldopacetamide Small molecule or natural product Click here for species-specific activity table Hs Inhibition - -
3-chlorotyrosine Small molecule or natural product Hs Inhibition - -
3-iodotyrosine Small molecule or natural product Hs Inhibition - -
alpha-methyltyrosine Small molecule or natural product Approved drug Primary target of this compound Hs Inhibition - -
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Segawa syndrome, autosomal recessive
Synonyms: Autosomal recessive dopa-responsive dystonia [Orphanet: ORPHA101150]
OMIM: 605407
Orphanet: ORPHA101150

References

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1. Joh TH, Park DH, Reis DJ. (1978) Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation. Proc Natl Acad Sci USA, 75 (10): 4744-8. [PMID:33381]

How to cite this page

Amino acid hydroxylases: L-Tyrosine hydroxylase . Last modified on 10/07/2018. Accessed on 23/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1243.