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GPR101

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Target not currently curated in GtoImmuPdb

Target id: 125

Nomenclature: GPR101

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 508 Xq26.3 GPR101 G protein-coupled receptor 101
Mouse 7 511 X A6 Gpr101 G protein-coupled receptor 101
Rat 7 508 Xq36 Gpr101 G protein-coupled receptor 101
Previous and Unofficial Names Click here for help
GPCR6
Database Links Click here for help
Specialist databases
GPCRdb gp101_human (Hs), gp101_mouse (Mm), d4abk4_rat (Rn)
Other databases
Alphafold Q96P66 (Hs), Q80T62 (Mm), D4ABK4 (Rn)
ChEMBL Target CHEMBL4523906 (Hs)
Ensembl Gene ENSG00000165370 (Hs), ENSMUSG00000036357 (Mm), ENSRNOG00000027658 (Rn)
Entrez Gene 83550 (Hs), 245424 (Mm), 317608 (Rn)
Human Protein Atlas ENSG00000165370 (Hs)
KEGG Gene hsa:83550 (Hs), mmu:245424 (Mm), rno:317608 (Rn)
OMIM 300393 (Hs)
Pharos Q96P66 (Hs)
RefSeq Nucleotide NM_054021 (Hs), NM_001108258 (Mm), NM_001033360 (Mm)
RefSeq Protein NP_473362 (Hs), NP_001028532 (Mm), NP_001101728 (Rn)
UniProtKB Q96P66 (Hs), Q80T62 (Mm), D4ABK4 (Rn)
Wikipedia GPR101 (Hs)
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gs family Adenylyl cyclase stimulation
Comments:  G-protein coupling predicted by knowledge-restricted hidden Markov model-based algorithm, and confirmed by mammalian and yeast cell transfection models [1].
References:  1
Tissue Distribution Click here for help
Caudate putamen, hypothalamus
Species:  Human
Technique:  Northern blot
References:  1,3
Brain, spinal cord
Species:  Mouse
Technique:  Northern blot
References:  1
Tissue Distribution Comments
Murine mRNA detected in all brain regions, with strongest signals in the hypothalamus. Prominent expression highly restricted to dopaminergic, serotonergic and noradrenergic nuclei [1].
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Clinically-Relevant Mutations and Pathophysiology Comments
Human missense SNP P432L (rs148692008; dbSNP) has been identified as associated with melanoma by whole exome sequencing, but remains untested [4].

Methylation of the GPR101 gene promoter in stage IV colorectal cancer is correlated with longer time to progression. Tumour specific hypermethylation observed [2].
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  V124L
Global MAF (%):  30
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 2|24|34|49
Minor allele count:  A=0.303/503
SNP accession:  VAR_049398, rs1190736
Validation:  1000 Genomes, HapMap
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  V238I
Global MAF (%):  1
Subpopulation MAF (%):  AFR|AMR: 4|1
Minor allele count:  T=0.011/18
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs139111924
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  L376P
Global MAF (%):  16
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 26|13|11|14
Minor allele count:  G=0.159/263
SNP accession:  VAR_049399, rs5931046
Validation:  1000 Genomes, HapMap
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  T293I
Global MAF (%):  5
Subpopulation MAF (%):  AFR|AMR|ASN: 19|1|1
Minor allele count:  A=0.050/83
SNP accession:  rs73566014
Validation:  1000 Genomes, Frequency

References

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1. Bates B, Zhang L, Nawoschik S, Kodangattil S, Tseng E, Kopsco D, Kramer A, Shan Q, Taylor N, Johnson J, Sun Y, Chen HM, Blatcher M, Paulsen JE, Pausch MH. (2006) Characterization of Gpr101 expression and G-protein coupling selectivity. Brain Res, 1087 (1): 1-14. [PMID:16647048]

2. Kober P, Bujko M, Olędzki J, Tysarowski A, Siedlecki JA. (2011) Methyl-CpG binding column-based identification of nine genes hypermethylated in colorectal cancer. Mol Carcinog, 50 (11): 846-56. [PMID:21438024]

3. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene, 275 (1): 83-91. [PMID:11574155]

4. Wei X, Walia V, Lin JC, Teer JK, Prickett TD, Gartner J, Davis S, NISC Comparative Sequencing Program, Stemke-Hale K, Davies MA et al.. (2011) Exome sequencing identifies GRIN2A as frequently mutated in melanoma. Nat Genet, 43 (5): 442-6. [PMID:21499247]

Contributors

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