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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 2346 | 17q12 | ACACA | acetyl-CoA carboxylase alpha | |
Mouse | - | 2345 | 11 C | Acaca | acetyl-Coenzyme A carboxylase alpha | |
Rat | - | 2345 | 10q26 | Acaca | acetyl-CoA carboxylase alpha |
Previous and Unofficial Names ![]() |
ACACA | ACAC | ACC | acetyl-CoA carboxylase alpha | ACCα |
Database Links ![]() |
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BRENDA | 6.4.1.2 |
CATH/Gene3D | 3.30.1490.20 |
ChEMBL Target | CHEMBL3351 (Hs), CHEMBL3086 (Mm), CHEMBL2397 (Rn) |
Ensembl Gene | ENSG00000132142 (Hs), ENSMUSG00000020532 (Mm), ENSRNOG00000034013 (Rn) |
Entrez Gene | 31 (Hs), 107476 (Mm), 60581 (Rn) |
Human Protein Atlas | ENSG00000132142 (Hs) |
KEGG Enzyme | 6.4.1.2 |
KEGG Gene | hsa:31 (Hs), mmu:107476 (Mm), rno:60581 (Rn) |
OMIM | 200350 (Hs) |
Pharos | Q13085 (Hs) |
UniProtKB | Q13085 (Hs), Q5SWU9 (Mm), P11497 (Rn) |
Wikipedia | ACACA (Hs) |
Enzyme Reaction ![]() |
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Products ![]() |
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Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Allosteric Modulators | |||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||
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1. Griffith DA, Dow RL, Huard K, Edmonds DJ, Bagley SW, Polivkova J, Zeng D, Garcia-Irizarry CN, Southers JA, Esler W et al.. (2013) Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure. J. Med. Chem., 56 (17): 7110-9. [PMID:23981033]
2. Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, Tong L, Saha AK, Westlin WF, Kapeller R et al.. (2016) Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc. Natl. Acad. Sci. U.S.A., 113 (13): E1796-805. [PMID:26976583]
3. Zhou W, Simpson PJ, McFadden JM, Townsend CA, Medghalchi SM, Vadlamudi A, Pinn ML, Ronnett GV, Kuhajda FP. (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res., 63 (21): 7330-7. [PMID:14612531]
Carboxylases: Acetyl-CoA carboxylase 1. Last modified on 14/02/2020. Accessed on 24/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1263.