Acetyl-CoA carboxylase 1 | Carboxylases | IUPHAR/BPS Guide to PHARMACOLOGY

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Acetyl-CoA carboxylase 1

Target not currently curated in GtoImmuPdb

Target id: 1263

Nomenclature: Acetyl-CoA carboxylase 1

Abbreviated Name: ACC1

Family: Carboxylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Contents:

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ACACA acetyl-CoA carboxylase alpha
Mouse - - Acaca acetyl-Coenzyme A carboxylase alpha
Rat - - Acaca acetyl-CoA carboxylase alpha
Previous and Unofficial Names
ACACA | ACAC | ACC | acetyl-CoA carboxylase alpha | ACCα
Database Links
BRENDA 6.4.1.2
CATH/Gene3D 3.30.1490.20
ChEMBL Target CHEMBL3351 (Hs), CHEMBL3086 (Mm), CHEMBL2397 (Rn)
Ensembl Gene ENSG00000132142 (Hs), ENSMUSG00000020532 (Mm), ENSRNOG00000034013 (Rn)
Entrez Gene 31 (Hs), 107476 (Mm), 60581 (Rn)
Human Protein Atlas ENSG00000132142 (Hs)
KEGG Enzyme 6.4.1.2
KEGG Gene hsa:31 (Hs), mmu:107476 (Mm), rno:60581 (Rn)
OMIM 200350 (Hs)
Pharos Q13085 (Hs)
UniProtKB Q13085 (Hs), Q5SWU9 (Mm), P11497 (Rn)
Wikipedia ACACA (Hs)
Enzyme Reaction
EC Number: 6.4.1.2
Products
Product Species Reference
Pi Human

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 21 [PMID: 23981033] Hs Inhibition 8.0 pIC50 1
⤷ pIC50 8.0 (IC50 1x10-8 M) [1]
TOFA Hs Inhibition 4.9 pIC50 3
⤷ pIC50 4.9 (IC50 1.23x10-5 M) [3]
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
firsocostat Hs Negative 8.7 pIC50 2
⤷ pIC50 8.7 (IC50 2.1x10-9 M) [2]

References

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1. Griffith DA, Dow RL, Huard K, Edmonds DJ, Bagley SW, Polivkova J, Zeng D, Garcia-Irizarry CN, Southers JA, Esler W et al.. (2013) Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure. J. Med. Chem., 56 (17): 7110-9. [PMID:23981033]

2. Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, Tong L, Saha AK, Westlin WF, Kapeller R et al.. (2016) Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc. Natl. Acad. Sci. U.S.A., 113 (13): E1796-805. [PMID:26976583]

3. Zhou W, Simpson PJ, McFadden JM, Townsend CA, Medghalchi SM, Vadlamudi A, Pinn ML, Ronnett GV, Kuhajda FP. (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res., 63 (21): 7330-7. [PMID:14612531]

How to cite this page

Carboxylases: Acetyl-CoA carboxylase 1. Last modified on 14/02/2020. Accessed on 09/04/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1263.