Acetyl-CoA carboxylase 1 | Carboxylases | IUPHAR/BPS Guide to PHARMACOLOGY

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Acetyl-CoA carboxylase 1

Target not currently curated in GtoImmuPdb

Target id: 1263

Nomenclature: Acetyl-CoA carboxylase 1

Abbreviated Name: ACC1

Family: Carboxylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ACACA acetyl-CoA carboxylase alpha
Mouse - - Acaca acetyl-Coenzyme A carboxylase alpha
Rat - - Acaca acetyl-CoA carboxylase alpha
Previous and Unofficial Names
ACACA | ACAC | ACC | acetyl-CoA carboxylase alpha | ACCα
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 6.4.1.2
Products
Product Species Reference
Pi Human

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 21 [PMID: 23981033] Hs Inhibition 8.0 pIC50 1
pIC50 8.0 (IC50 1x10-8 M) [1]
TOFA Hs Inhibition 4.9 pIC50 3
pIC50 4.9 (IC50 1.23x10-5 M) [3]
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
firsocostat Hs Negative 8.7 pIC50 2
pIC50 8.7 (IC50 2.1x10-9 M) [2]

References

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1. Griffith DA, Dow RL, Huard K, Edmonds DJ, Bagley SW, Polivkova J, Zeng D, Garcia-Irizarry CN, Southers JA, Esler W et al.. (2013) Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure. J. Med. Chem., 56 (17): 7110-9. [PMID:23981033]

2. Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, Tong L, Saha AK, Westlin WF, Kapeller R et al.. (2016) Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc. Natl. Acad. Sci. U.S.A., 113 (13): E1796-805. [PMID:26976583]

3. Zhou W, Simpson PJ, McFadden JM, Townsend CA, Medghalchi SM, Vadlamudi A, Pinn ML, Ronnett GV, Kuhajda FP. (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res., 63 (21): 7330-7. [PMID:14612531]

How to cite this page

Carboxylases: Acetyl-CoA carboxylase 1. Last modified on 14/02/2020. Accessed on 09/04/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1263.