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γ-Glutamyl carboxylase

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Target not currently curated in GtoImmuPdb

Target id: 1268

Nomenclature: γ-Glutamyl carboxylase

Abbreviated Name: GGCX

Family: Carboxylases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 5 758 2p11.2 GGCX gamma-glutamyl carboxylase
Mouse 5 757 6 C1 Ggcx gamma-glutamyl carboxylase
Rat 5 758 4q31 Ggcx gamma-glutamyl carboxylase
Previous and Unofficial Names Click here for help
vitamin K-dependent gamma-carboxylase | peptidyl-glutamate 4-carboxylase | vitamin K gamma glutamyl carboxylase | VKCFD1
Database Links Click here for help
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 4.1.1.90
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
glutamyl peptides Substrate is endogenous in the given species Hs - -
Cofactors Click here for help
Cofactor Species Comments Reference
NADPH Human
vitamin K hydroquinone Human

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
anisindione Small molecule or natural product Approved drug Primary target of this compound Hs Inhibition - -
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
Synonyms: Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency [Orphanet: ORPHA91135]
OMIM: 610842
Orphanet: ORPHA91135
Disease:  Vitamin K-dependent clotting factors, combined deficiency of, 1; VKCFD1
Synonyms: Hereditary combined deficiency of vitamin K-dependent clotting factors [Orphanet: ORPHA98434]
OMIM: 277450
Orphanet: ORPHA98434

How to cite this page

Carboxylases: γ-Glutamyl carboxylase. Last modified on 14/02/2017. Accessed on 23/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1268.