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Malonyl-CoA decarboxylase

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Target not currently curated in GtoImmuPdb

Target id: 1275

Nomenclature: Malonyl-CoA decarboxylase

Abbreviated Name: MLYCD

Family: Decarboxylases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 493 16q23.3 MLYCD malonyl-CoA decarboxylase
Mouse - 492 8 E1 Mlycd malonyl-CoA decarboxylase
Rat - 492 19q12 Mlycd malonyl-CoA decarboxylase
Previous and Unofficial Names Click here for help
MCD | malonyl-CoA decarboxylase, mitochondrial
Database Links Click here for help
Alphafold O95822 (Hs), Q99J39 (Mm), Q920F5 (Rn)
BRENDA 4.1.1.9
ChEMBL Target CHEMBL4698 (Hs), CHEMBL1255162 (Mm)
Ensembl Gene ENSG00000103150 (Hs), ENSMUSG00000074064 (Mm), ENSRNOG00000014522 (Rn)
Entrez Gene 23417 (Hs), 56690 (Mm), 85239 (Rn)
Human Protein Atlas ENSG00000103150 (Hs)
KEGG Enzyme 4.1.1.9
KEGG Gene hsa:23417 (Hs), mmu:56690 (Mm), rno:85239 (Rn)
OMIM 606761 (Hs)
Pharos O95822 (Hs)
UniProtKB O95822 (Hs), Q99J39 (Mm), Q920F5 (Rn)
Wikipedia MLYCD (Hs)
Enzyme Reaction Click here for help
EC Number: 4.1.1.9

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 10h [PMID: 20832306] Small molecule or natural product Hs Inhibition 9.3 pIC50 1
⤷ pIC50 9.3 (IC50 5x10-10 M) [1]

References

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1. Tang H, Yan Y, Feng Z, de Jesus RK, Yang L, Levorse DA, Owens KA, Akiyama TE, Bergeron R, Castriota GA et al.. (2010) Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. Bioorg Med Chem Lett, 20 (20): 6088-92. [PMID:20832306]

How to cite this page

Decarboxylases: Malonyl-CoA decarboxylase. Last modified on 10/07/2018. Accessed on 31/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1275.