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GPR135

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Target not currently curated in GtoImmuPdb

Target id: 129

Nomenclature: GPR135

Family: Class A Orphans

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 494 14q23.1 GPR135 G protein-coupled receptor 135
Mouse 7 457 12 C3 Gpr135 G protein-coupled receptor 135
Rat 7 457 6q24 Gpr135 G protein-coupled receptor 135
Previous and Unofficial Names Click here for help
HUMNPIIY20 | PAFR
Database Links Click here for help
Specialist databases
GPCRDB gp135_human (Hs), gp135_mouse (Mm), gp135_rat (Rn)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution Click here for help
Neuron, stomach, eye, cervix, testis
Species:  Human
Technique:  Expressed sequence tag
References:  1
Pituitary
Species:  Human
Technique:  Northern Blot
References:  2
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S191N
Global MAF (%):  1
Subpopulation MAF (%):  ASN: 3
Minor allele count:  T=0.007/16
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  V481A
Global MAF (%):  2
Subpopulation MAF (%):  AFR: 9
Minor allele count:  G=0.020/44
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  Q5P
Global MAF (%):  47
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 53|24|45|55
Minor allele count:  G=0.468/1023
SNP accession: 
Validation:  1000 Genomes

References

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1. Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2003) Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett, 554 (3): 381-8. [PMID:14623098]

2. Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF. (2003) Novel human G-protein-coupled receptors. Biochem Biophys Res Commun, 305 (1): 67-71. [PMID:12732197]

Contributors

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