<i>GPR135</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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GPR135

Target not currently curated in GtoImmuPdb

Target id: 129

Nomenclature: GPR135

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 494 14q22.3 GPR135 G protein-coupled receptor 135
Mouse 7 457 12 C3 Gpr135 G protein-coupled receptor 135
Rat 7 457 6q24 Gpr135 G protein-coupled receptor 135
Previous and Unofficial Names
HUMNPIIY20 | PAFR
Database Links
Specialist databases
GPCRDB gp135_human (Hs), gp135_mouse (Mm), gp135_rat (Rn)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution
Neuron, stomach, eye, cervix, testis
Species:  Human
Technique:  Expressed sequence tag
References:  1
Pituitary
Species:  Human
Technique:  Northern Blot
References:  2
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S191N
Global MAF (%):  1
Subpopulation MAF (%):  ASN: 3
Minor allele count:  T=0.007/16
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  V481A
Global MAF (%):  2
Subpopulation MAF (%):  AFR: 9
Minor allele count:  G=0.020/44
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  Q5P
Global MAF (%):  47
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 53|24|45|55
Minor allele count:  G=0.468/1023
SNP accession: 
Validation:  1000 Genomes

References

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1. Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2003) Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett., 554 (3): 381-8. [PMID:14623098]

2. Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF. (2003) Novel human G-protein-coupled receptors. Biochem. Biophys. Res. Commun., 305 (1): 67-71. [PMID:12732197]

Contributors

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