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CYP1B1

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Target not currently curated in GtoImmuPdb

Target id: 1320

Nomenclature: CYP1B1

Family: CYP1 family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 543 2p22.2 CYP1B1 cytochrome P450 family 1 subfamily B member 1
Mouse - 543 17 E3 Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1
Rat - 543 6q11 Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1
Previous and Unofficial Names Click here for help
GLC3A | cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile) | cytochrome P450, subfamily 1B, polypeptide 1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | cytochrome P450, family 1, subfamily b, polypeptide 1 | cytochrome P450
Database Links Click here for help
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.14.1.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
chrysin Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.8 pKi 1
pKi 7.8 (Ki 1.6x10-8 M) [1]
5H3'FPE Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.6 pIC50 2
pIC50 7.6 (IC50 2.4x10-8 M) [2]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0010575 positive regulation of vascular endothelial growth factor production ISS
GO:0071356 cellular response to tumor necrosis factor IEP
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0071603 endothelial cell-cell adhesion IEA

References

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1. Androutsopoulos VP, Papakyriakou A, Vourloumis D, Spandidos DA. (2011) Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg Med Chem, 19 (9): 2842-9. [PMID:21482471]

2. Liu J, Taylor SF, Dupart PS, Arnold CL, Sridhar J, Jiang Q, Wang Y, Skripnikova EV, Zhao M, Foroozesh M. (2013) Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1. J Med Chem, 56 (10): 4082-92. [PMID:23600958]

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