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CYP1B1

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Target not currently curated in GtoImmuPdb

Target id: 1320

Nomenclature: CYP1B1

Family: CYP1 family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 543 2p22.2 CYP1B1 cytochrome P450 family 1 subfamily B member 1
Mouse - 543 17 E3 Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1
Rat - 543 6q11 Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1
Previous and Unofficial Names Click here for help
GLC3A | cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile) | cytochrome P450, subfamily 1B, polypeptide 1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | cytochrome P450, family 1, subfamily b, polypeptide 1 | cytochrome P450
Database Links Click here for help
Alphafold Q16678 (Hs), Q64429 (Mm), Q64678 (Rn)
BRENDA 1.14.1.1
ChEMBL Target CHEMBL4878 (Hs)
Ensembl Gene ENSG00000138061 (Hs), ENSMUSG00000024087 (Mm), ENSRNOG00000040287 (Rn)
Entrez Gene 1545 (Hs), 13078 (Mm), 25426 (Rn)
Human Protein Atlas ENSG00000138061 (Hs)
KEGG Enzyme 1.14.1.1
KEGG Gene hsa:1545 (Hs), mmu:13078 (Mm), rno:25426 (Rn)
OMIM 601771 (Hs)
Pharos Q16678 (Hs)
UniProtKB Q16678 (Hs), Q64429 (Mm), Q64678 (Rn)
Wikipedia CYP1B1 (Hs)
Enzyme Reaction Click here for help
EC Number: 1.14.1.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
chrysin Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.8 pKi 1
⤷ pKi 7.8 (Ki 1.6x10-8 M) [1]
2,3',4,5'-Tetramethoxystilbene Small molecule or natural product Hs Inhibition 8.2 pIC50 2
⤷ pIC50 8.2 (IC50 6x10-9 M) [2]
5H3'FPE Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.6 pIC50 3
⤷ pIC50 7.6 (IC50 2.4x10-8 M) [3]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process:  Barrier integrity

References

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1. Androutsopoulos VP, Papakyriakou A, Vourloumis D, Spandidos DA. (2011) Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg Med Chem, 19 (9): 2842-9. [PMID:21482471]

2. Kim S, Ko H, Park JE, Jung S, Lee SK, Chun YJ. (2002) Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem, 45 (1): 160-4. [PMID:11754588]

3. Liu J, Taylor SF, Dupart PS, Arnold CL, Sridhar J, Jiang Q, Wang Y, Skripnikova EV, Zhao M, Foroozesh M. (2013) Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1. J Med Chem, 56 (10): 4082-92. [PMID:23600958]

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