<i>GPR152</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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GPR152

Target not currently curated in GtoImmuPdb

Target id: 138

Nomenclature: GPR152

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 470 11q13.1 GPR152 G protein-coupled receptor 152
Mouse 7 511 19 A Gpr152 G protein-coupled receptor 152
Rat 7 394 1q42 Gpr152 G protein-coupled receptor 152
Previous and Unofficial Names
PGR1 | PGR5 | G-protein coupled receptor PGR5
Database Links
Specialist databases
GPCRDB gp152_human (Hs), gp152_mouse (Mm)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  L317V
Global MAF (%):  9
Subpopulation MAF (%):  AFR|AMR: 39|2
Minor allele count:  C=0.093/204
SNP accession: 
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  G61R
Global MAF (%):  5
Subpopulation MAF (%):  AMR|ASN: 1|19
Minor allele count:  T=0.054/118
SNP accession: 
Validation:  1000 Genomes, Frequency
General Comments
GPR152 is found to be most closely related to the gamma-group of Rhodopsin family [1].

References

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1. Gloriam DE, Schiöth HB, Fredriksson R. (2005) Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim. Biophys. Acta, 1722 (3): 235-46. [PMID:15777626]

Contributors

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