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12S-LOX

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Target not currently curated in GtoImmuPdb

Target id: 1387

Nomenclature: 12S-LOX

Family: Lipoxygenases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 663 17p13.1 ALOX12 arachidonate 12-lipoxygenase, 12S type
Mouse - 663 11 42.99 cM Alox12 arachidonate 12-lipoxygenase
Rat - 663 10q24 Alox12 arachidonate 12-lipoxygenase, 12S type
Previous and Unofficial Names Click here for help
arachidonate 12-lipoxygenase, 12S-type | platelet-type lipoxygenase 12 | arachidonate 12-lipoxygenase, 12S type
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.13.11.31
Description Reaction Reference
Arachidonic acid + O2 => 12S-HPETE

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ML355 Small molecule or natural product Primary target of this compound Hs Inhibition 6.5 pIC50 1
pIC50 6.5 (IC50 3.4x10-7 M) [1]

References

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1. Luci DK, Jameson 2nd JB, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J et al.. (2014) Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem, 57 (2): 495-506. [PMID:24393039]

Contributors

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