<i>N</i>-Acylphosphatidylethanolamine-phospholipase D | <i>N</i>-Acylethanolamine turnover | IUPHAR/BPS Guide to PHARMACOLOGY

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N-Acylphosphatidylethanolamine-phospholipase D

Target not currently curated in GtoImmuPdb

Target id: 1398

Nomenclature: N-Acylphosphatidylethanolamine-phospholipase D

Abbreviated Name: NAPE-PLD

Family: N-Acylethanolamine turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - NAPEPLD N-acyl phosphatidylethanolamine phospholipase D
Mouse - - Napepld N-acyl phosphatidylethanolamine phospholipase D
Rat - - Napepld N-acyl phosphatidylethanolamine phospholipase D
Previous and Unofficial Names
chromosome 7 open reading frame 18, N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | FMP30
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
LEI-401 Hs Inhibition 7.6 pKi 3
pKi 7.6 (Ki 2.7x10-8 M) [3]
Description: hNAPE-PLD in vitro activity assay.
hexachlorophene Hs Inhibition 5.0 pIC50 1
pIC50 5.0 (IC50 9.8x10-6 M) [1]
bithionol Hs Inhibition 5.0 pIC50 1
pIC50 5.0 (IC50 1.07x10-5 M) [1]
ARN19874 Hs Inhibition 4.5 pIC50 2
pIC50 4.5 (IC50 3.37x10-5 M) [2]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0050729 positive regulation of inflammatory response ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0050729 positive regulation of inflammatory response ISS

References

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1. Aggarwal G, Zarrow JE, Mashhadi Z, Flynn CR, Vinson P, Weaver CD, Davies SS. (2020) Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D. J. Biol. Chem., 295 (21): 7289-7300. [PMID:32284327]

2. Castellani B, Diamanti E, Pizzirani D, Tardia P, Maccesi M, Realini N, Magotti P, Garau G, Bakkum T, Rivara S et al.. (2017) Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD). Chem. Commun. (Camb.), 53 (95): 12814-12817. [PMID:29143042]

3. Mock ED, Mustafa M, Gunduz-Cinar O, Cinar R, Petrie GN, Kantae V, Di X, Ogasawara D, Varga ZV, Paloczi J et al.. (2020) Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice. Nat. Chem. Biol., 16 (6): 667-675. [PMID:32393901]

Contributors

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