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cPLA2-4A

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Target not currently curated in GtoImmuPdb

Target id: 1424

Nomenclature: cPLA2-4A

Family: Phospholipase A2

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 749 1q31.1 PLA2G4A phospholipase A2 group IVA
Mouse - 748 1 63.51 cM Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent)
Rat - 752 13q21 Pla2g4a phospholipase A2 group IVA
Previous and Unofficial Names Click here for help
Calcium-dependent PLA2 | cytosolic phospholipase A2 α | GIVA | phospholipase A2 group IVA | Pla2c | cPLA2-alpha | cytosolic PLA2 | phospholipase A2, group IVA (cytosolic, calcium-dependent) | phospholipase A2
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
Pharos
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.1.1.4

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 57 [PMID: 16610804] Small molecule or natural product Hs Inhibition 8.4 pIC50 1
pIC50 8.4 (IC50 4.3x10-9 M) [1]
Description: Inhibition of human isolated cPLA2-4A in a lipid vesicle assay.
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0031622 positive regulation of fever generation IEP
GO:0050729 positive regulation of inflammatory response ISO
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GO:0002827 positive regulation of T-helper 1 type immune response IEA
GO:0043032 positive regulation of macrophage activation IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0031622 positive regulation of fever generation IEP
GO:0050729 positive regulation of inflammatory response ISO
click arrow to show/hide IEA associations
GO:0043032 positive regulation of macrophage activation IEA

References

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1. Ludwig J, Bovens S, Brauch C, Elfringhoff AS, Lehr M. (2006) Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha. J Med Chem, 49 (8): 2611-20. [PMID:16610804]

How to cite this page

Phospholipase A2: cPLA2-4A. Last modified on 16/09/2015. Accessed on 26/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1424.