Quaternary Structure: Complexes

protein kinase A

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	381	17q24.2	PRKAR1A	protein kinase cAMP-dependent type I regulatory subunit alpha
Mouse	-	381	11 72.33 cM	Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha
Rat	-	381	10q32.1	Prkar1a	protein kinase cAMP-dependent type I regulatory subunit alpha

Previous and Unofficial Names

TSE1 | tissue specific extinguisher 1 | protein kinase, cAMP dependent regulatory, type I, alpha | RIIA | RIalpha | PRKAR1 | protein kinase, cAMP-dependent, regulatory subunit type I alpha | protein kinase | protein kinase cAMP-dependent type 1 regulatory subunit alpha

Database Links
Alphafold	P10644 (Hs), Q9DBC7 (Mm), P09456 (Rn)
CATH/Gene3D	2.60.120.10
ChEMBL Target	CHEMBL4928 (Hs)
Ensembl Gene	ENSG00000108946 (Hs), ENSMUSG00000020612 (Mm), ENSRNOG00000049876 (Rn)
Entrez Gene	5573 (Hs), 19084 (Mm), 25725 (Rn)
Human Protein Atlas	ENSG00000108946 (Hs)
KEGG Gene	hsa:5573 (Hs), mmu:19084 (Mm), rno:25725 (Rn)
OMIM	188830 (Hs)
Orphanet	ORPHA118010 (Hs)
Pharos	P10644 (Hs)
RefSeq Nucleotide	NM_002734 (Hs), NM_212471 (Hs), NM_212472 (Hs), NM_001276289 (Hs), NM_001276290 (Hs), NM_021880 (Mm), NM_013181 (Rn)
RefSeq Protein	NP_001263219 (Hs), NP_997636 (Hs), NP_997637 (Hs), NP_001263218 (Hs), NP_068680 (Mm), NP_037313 (Rn)
UniProtKB	P10644 (Hs), Q9DBC7 (Mm), P09456 (Rn)
Wikipedia	PRKAR1A (Hs)

Immuno Process Associations

Immuno Process:  T cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Chemotaxis & migration

Immuno Process:  Cellular signalling

Clinically-Relevant Mutations and Pathophysiology
Disease:  Acrodysostosis 1 with or without hormone resistance; ACRDYS1 Synonyms: Acrodysostosis [Orphanet: ORPHA950] [Disease Ontology: DOID:14669] Acrodysostosis with multiple hormone resistance [Orphanet: ORPHA280651] Disease Ontology: DOID:14669 OMIM: 101800 Orphanet: ORPHA950, ORPHA280651
Disease:  Carney complex, type 1; CNC1 Synonyms: Carney complex [Orphanet: ORPHA1359] [Disease Ontology: DOID:0050471] Disease Ontology: DOID:0050471 OMIM: 160980 Orphanet: ORPHA1359
Disease:  Myxoma, intracardiac OMIM: 255960 Orphanet: ORPHA615
Disease:  Pigmented nodular adrenocortical disease, primary, 1; PPNAD1 Synonyms: Primary pigmented nodular adrenocortical disease [Orphanet: ORPHA189439] OMIM: 610489 Orphanet: ORPHA189439