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protein kinase, cAMP-dependent, catalytic, gamma subunit

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Target not currently curated in GtoImmuPdb

Target id: 1478

Nomenclature: protein kinase, cAMP-dependent, catalytic, gamma subunit

Abbreviated Name: PKACg

Family: Protein kinase A (PKA) family

Contents:

Quaternary Structure: Complexes
protein kinase A
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 351 9q21.11 PRKACG protein kinase cAMP-activated catalytic subunit gamma
Previous and Unofficial Names Click here for help
protein kinase, cAMP-dependent, gamma catalytic subunit
Database Links Click here for help
Alphafold P22612 (Hs)
BRENDA 2.7.11.11
ChEMBL Target CHEMBL2743 (Hs)
Ensembl Gene ENSG00000165059 (Hs)
Entrez Gene 5568 (Hs)
Human Protein Atlas ENSG00000165059 (Hs)
KEGG Enzyme 2.7.11.11
KEGG Gene hsa:5568 (Hs)
OMIM 176893 (Hs)
Pharos P22612 (Hs)
RefSeq Nucleotide NM_002732 (Hs)
RefSeq Protein NP_002723 (Hs)
UniProtKB P22612 (Hs)
Wikipedia PRKACG (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.11
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx

Reference: ...1
Key to terms and symbols Click column headers to sort
Target used in screen: nd/PKAcg
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 3.0
K-252a Small molecule or natural product Hs Inhibitor Inhibition 10.8
SB 218078 Small molecule or natural product Hs Inhibitor Inhibition 39.8
PP1 analog II Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 55.2
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 58.1
SB202190 Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 78.4
LY 303511 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 83.2
VEGF receptor tyrosine kinase inhibitor II Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 87.4
PKR inhibitor Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 87.6
semaxanib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 87.6
Displaying the top 10 most potent ligands  View all ligands in screen »
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cellular signalling

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]

How to cite this page

Protein kinase A (PKA) family: protein kinase, cAMP-dependent, catalytic, gamma subunit. Last modified on 20/03/2013. Accessed on 07/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1478.