Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	879	10p12.1	MASTL	microtubule associated serine/threonine kinase like
Mouse	-	865	2 A3	Mastl	microtubule associated serine/threonine kinase-like
Rat	-	866	17q12.3	Mastl	microtubule associated serine/threonine kinase-like

Previous and Unofficial Names

GWL | GWLlGwl | Serine/threonine-protein kinase greatwall | THC2 | microtubule associated serine/threonine kinase-like

Database Links
Alphafold	Q96GX5 (Hs), Q8C0P0 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL4105826 (Hs)
Ensembl Gene	ENSG00000120539 (Hs), ENSMUSG00000026779 (Mm), ENSRNOG00000054474 (Rn)
Entrez Gene	84930 (Hs), 67121 (Mm), 307169 (Rn)
Human Protein Atlas	ENSG00000120539 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:84930 (Hs), mmu:67121 (Mm), rno:307169 (Rn)
OMIM	608221 (Hs)
Orphanet	ORPHA123154 (Hs)
Pharos	Q96GX5 (Hs)
RefSeq Nucleotide	NM_001172303 (Hs), NM_025979 (Mm), NM_001107369 (Rn)
RefSeq Protein	NP_116233 (Hs), NP_080255 (Mm), NP_001100839 (Rn)
UniProtKB	Q96GX5 (Hs), Q8C0P0 (Mm)
Wikipedia	MASTL (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference ARPP19 Hs - - 1

Clinically-Relevant Mutations and Pathophysiology
Disease:  Thrombocytopenia 2; THC2 Synonyms: Autosomal thrombocytopenia with normal platelets [Orphanet: ORPHA168629] Thrombocytopenia [Disease Ontology: DOID:1588] Disease Ontology: DOID:1588 OMIM: 188000 Orphanet: ORPHA168629

General Comments
Phosphorylates the ARPP19 protein that acts as a substrate-competitive inhibitor of the protein phosphatase 2A (PP2A)/B55 phosphatase complex, to regulate the cell cycle [1].