Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	559	5p13.1	PRKAA1	protein kinase AMP-activated catalytic subunit alpha 1
Mouse	-	559	15 A1	Prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit
Rat	-	559	2q16	Prkaa1	protein kinase AMP-activated catalytic subunit alpha 1

Previous and Unofficial Names

AMPK, alpha, 1 | AMPK alpha-1 chain | AMPK subunit alpha-1 | tau-protein kinase PRKAA1 | ACACA kinase | acetyl-CoA carboxylase kinase | HMGCR kinase | hydroxymethylglutaryl-CoA reductase kinase | AMPKa1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | protein kinase

Database Links
Alphafold	Q13131 (Hs), Q5EG47 (Mm), P54645 (Rn)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL4045 (Hs), CHEMBL1075161 (Mm), CHEMBL4533 (Rn)
DrugBank Target	Q13131 (Hs)
Ensembl Gene	ENSG00000132356 (Hs), ENSMUSG00000050697 (Mm), ENSRNOG00000012799 (Rn)
Entrez Gene	5562 (Hs), 105787 (Mm), 65248 (Rn)
Human Protein Atlas	ENSG00000132356 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:5562 (Hs), mmu:105787 (Mm), rno:65248 (Rn)
OMIM	602739 (Hs)
Pharos	Q13131 (Hs)
RefSeq Nucleotide	NM_006251 (Hs), NM_001013367 (Mm), NM_019142 (Rn)
RefSeq Protein	NP_006242 (Hs), NP_001013385 (Mm), NP_062015 (Rn)
UniProtKB	Q13131 (Hs), Q5EG47 (Mm), P54645 (Rn)
Wikipedia	PRKAA1 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,3
Key to terms and symbols		Click column headers to sort
Target used in screen: AMPK-alpha1
Ligand Sp. Type Action Value Parameter staurosporine Hs Inhibitor Inhibition 8.4 pKd sunitinib Hs Inhibitor Inhibition 7.7 pKd lestaurtinib Hs Inhibitor Inhibition 7.6 pKd NVP-TAE684 Hs Inhibitor Inhibition 7.6 pKd SU-14813 Hs Inhibitor Inhibition 7.0 pKd midostaurin Hs Inhibitor Inhibition 6.7 pKd JNJ-28312141 Hs Inhibitor Inhibition 6.7 pKd tamatinib Hs Inhibitor Inhibition 6.5 pKd PHA-665752 Hs Inhibitor Inhibition 6.5 pKd KW-2449 Hs Inhibitor Inhibition 6.4 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 2...
Key to terms and symbols		Click column headers to sort
Target used in screen: AMPKα1/nd
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM Tpl2 kinase inhibitor Hs Inhibitor Inhibition -2.0 -1.0 Cdk1/2 inhibitor III Hs Inhibitor Inhibition -2.0 -1.0 K-252a Hs Inhibitor Inhibition -1.0 0.0 staurosporine Hs Inhibitor Inhibition -0.5 0.0 GSK-3 inhibitor IX Hs Inhibitor Inhibition 2.0 10.0 indirubin-3'-monoxime Hs Inhibitor Inhibition 2.0 0.0 indirubin derivative E804 Hs Inhibitor Inhibition 4.0 4.0 JAK3 inhibitor VI Hs Inhibitor Inhibition 6.0 1.0 SU11652 Hs Inhibitor Inhibition 7.0 3.0 Syk inhibitor Hs Inhibitor Inhibition 9.0 4.0
Displaying the top 10 most potent ligands  View all ligands in screen »