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MRGPRG

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Target not currently curated in GtoImmuPdb

Target id: 155

Nomenclature: MRGPRG

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 289 11p15.4 MRGPRG MAS related GPR family member G
Mouse 7 289 7 F5 Mrgprg MAS-related GPR, member G
Rat 7 289 1q42 Mrgprg MAS related GPR family member G
Previous and Unofficial Names Click here for help
EBRT2 | GPR169 | MRGG | MAS-related gene G | MAS-related GPR
Database Links Click here for help
Specialist databases
GPCRdb mrgrg_human (Hs), mrgrg_mouse (Mm), mrgrg_rat (Rn)
Other databases
Alphafold Q86SM5 (Hs), Q91ZB5 (Mm), Q7TN39 (Rn)
ChEMBL Target CHEMBL4523881 (Hs)
Ensembl Gene ENSG00000182170 (Hs), ENSMUSG00000050276 (Mm), ENSRNOG00000069807 (Rn)
Entrez Gene 386746 (Hs), 381974 (Mm), 309133 (Rn)
Human Protein Atlas ENSG00000182170 (Hs)
KEGG Gene hsa:386746 (Hs), mmu:381974 (Mm), rno:309133 (Rn)
OMIM 607234 (Hs)
Pharos Q86SM5 (Hs)
RefSeq Nucleotide NM_001164377 (Hs), NM_203492 (Mm), NM_203470 (Rn)
RefSeq Protein NP_001157849 (Hs), NP_987077 (Mm), NP_982296 (Rn)
UniProtKB Q86SM5 (Hs), Q91ZB5 (Mm), Q7TN39 (Rn)
Wikipedia MRGPRG (Hs)
Tissue Distribution Comments
MRGPRG was not detectable by in situ hybridisation in dorsal root ganglia [2].
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  T19R
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR: 12|1
Minor allele count:  C=0.029/63
SNP accession:  rs74049082
Validation:  1000 Genomes
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  G287V
Global MAF (%):  4
Subpopulation MAF (%):  AFR|AMR: 18|2
Minor allele count:  A=0.044/96
SNP accession:  rs75066302
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  A162V
Global MAF (%):  1
Subpopulation MAF (%):  AFR|AMR|EUR: 1|3|2
Minor allele count:  A=0.014/31
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs75003193
Validation:  1000 Genomes
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  A76T
Global MAF (%):  4
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 11|3|2|3
Minor allele count:  T=0.044/96
SNP accession:  rs111693331
Validation:  1000 Genomes, Frequency, Cluster
General Comments
Of the eight human Mas-related GPCRs (MRGs), four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) have clear orthologues in rodents, whereas the cluster of genes including human MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 is found only in primates and is replaced in rodents with a family of genes (>25 in mice, ~10 in rats) which have no obvious human counterparts [2]. Certain rodent MRGs have been reported to respond to adenine [1] and to RF-amide peptides including neuropeptide FF [3-4] but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [5-6].

References

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1. Bender E, Buist A, Jurzak M, Langlois X, Baggerman G, Verhasselt P, Ercken M, Guo HQ, Wintmolders C, Van den Wyngaert I et al.. (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc Natl Acad Sci USA, 99 (13): 8573-8. [PMID:12084918]

2. Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ. (2001) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell, 106 (5): 619-32. [PMID:11551509]

3. Han SK, Dong X, Hwang JI, Zylka MJ, Anderson DJ, Simon MI. (2002) Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Proc Natl Acad Sci USA, 99 (23): 14740-5. [PMID:12397184]

4. Lee MG, Dong X, Liu Q, Patel KN, Choi OH, Vonakis B, Undem BJ. (2008) Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions. J Immunol, 180 (4): 2251-5. [PMID:18250432]

5. Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, Ru F, Guan Y, Weng HJ, Geng Y, Undem BJ, Kollarik M, Chen ZF, Anderson DJ, Dong X. (2009) Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell, 139 (7): 1353-65. [PMID:20004959]

6. Wilson SR, Gerhold KA, Bifolck-Fisher A, Liu Q, Patel KN, Dong X, Bautista DM. (2011) TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat Neurosci, 14 (5): 595-602. [PMID:21460831]

Contributors

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