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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 480 | 20q13.12 | CTSA | cathepsin A | |
Mouse | - | 474 | 2 85.27 cM | Ctsa | cathepsin A | |
Rat | - | 456 | 3q42 | Ctsa | cathepsin A |
Database Links | |
Specialist databases | |
MEROPS | S10.002 (Hs) |
Other databases | |
Alphafold | P10619 (Hs), P16675 (Mm), Q6AYS3 (Rn) |
BRENDA | 3.4.16.5 |
CATH/Gene3D | 3.40.50.1820 |
ChEMBL Target | CHEMBL6115 (Hs), CHEMBL3259490 (Mm) |
Ensembl Gene | ENSG00000064601 (Hs), ENSMUSG00000017760 (Mm), ENSRNOG00000015857 (Rn) |
Entrez Gene | 5476 (Hs), 19025 (Mm), 296370 (Rn) |
Human Protein Atlas | ENSG00000064601 (Hs) |
KEGG Enzyme | 3.4.16.5 |
KEGG Gene | hsa:5476 (Hs), mmu:19025 (Mm), rno:296370 (Rn) |
OMIM | 613111 (Hs) |
Orphanet | ORPHA120888 |
Pharos | P10619 (Hs) |
RefSeq Nucleotide | NM_000308 (Hs), NM_001167594 (Hs), NM_001127695 (Hs), NM_001038492 (Mm), NM_001011959 (Rn) |
RefSeq Protein | NP_000299 (Hs), NP_001121167 (Hs), NP_001161066 (Hs), NP_001033581 (Mm), NP_001011959 (Rn) |
UniProtKB | P10619 (Hs), P16675 (Mm), Q6AYS3 (Rn) |
Wikipedia | CTSA (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||
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1. Ruf S et al.. (2013) Use of boceprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases. Patent number: WO2013072327. Assignee: Sanofi. Priority date: 14/11/2011. Publication date: 23/05/2013.
2. Ruf S et al. (2013) Use of telaprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases. Patent number: WO2013072328. Assignee: Sanofi. Priority date: 14/11/2011. Publication date: 23/05/2013.
3. Ruf S et al. (2014) Biaryl-propionic acid derivatives and their use as pharmaceuticals. Patent number: WO2014154727. Assignee: Sanofi. Priority date: 20/03/2013. Publication date: 02/10/2014.
4. Ruf S, Buning C, Schreuder H, Horstick G, Linz W, Olpp T, Pernerstorfer J, Hiss K, Kroll K, Kannt A et al.. (2012) Novel β-amino acid derivatives as inhibitors of cathepsin A. J Med Chem, 55 (17): 7636-49. [PMID:22861813]
S10: Carboxypeptidase Y: Cathepsin A. Last modified on 05/11/2014. Accessed on 08/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1581.