M28: Aminopeptidase Y | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

M28: Aminopeptidase Y C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

1608

Folate hydrolase 1B Show summary »« Hide summary

Target Id	1607
Nomenclature	Folate hydrolase 1B
Previous and unofficial names	FOLH2 \| FOLHP \| GCPIII \| PSMAL \| folate hydrolase 2 \| glutamate carboxypeptidase III \| prostate specific membrane antigen like protein \| folate hydrolase 1B
Genes	FOLH1B (Hs)
Ensembl ID	ENSG00000134612 (Hs)
UniProtKB AC	Q9HBA9 (Hs)

Folate hydrolase (prostate-specific membrane antigen) 1 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1606

Nomenclature

Folate hydrolase (prostate-specific membrane antigen) 1

Previous and unofficial names

Genes

FOLH1 (Hs), Folh1 (Mm), Folh1 (Rn)

Ensembl ID

ENSG00000086205 (Hs), ENSMUSG00000001773 (Mm), ENSRNOG00000013770 (Rn)

UniProtKB AC

Q04609 (Hs), O35409 (Mm), P70627 (Rn)

EC number

3.4.17.21

Inhibitors

vipivotide tetraxetan pK_i 9.4 [1]

Antibodies

capromab (Binding)

Comment

Folate hydrolase is also known as NAALADase as it is responsible for the hydrolysis of N-acetaspartylglutamate to form N-acetylaspartate and L-glutamate (L-glutamic acid). In the gut, the enzyme assists in the assimilation of folate by hydrolysing dietary poly-gamma-glutamylfolate. The enzyme is highly expressed in the prostate, and its expression is up-regulated in cancerous tissue. A tagged version of the antibody capromab has been used for imaging purposes.

glutaminyl-peptide cyclotransferase Show summary »« Hide summary More detailed page go icon to follow link

N-Acetylated α-linked acidic dipeptidase-like 1 Show summary »« Hide summary

Target Id

1608

Nomenclature

N-Acetylated α-linked acidic dipeptidase-like 1

Previous and unofficial names

ileal peptidase I100 | 100 kDa ileum brush border membrane protein | ileal dipeptidylpeptidase | NAALADase L

Genes

NAALADL1 (Hs), Naaladl1 (Mm), Naaladl1 (Rn)

Ensembl ID

ENSG00000168060 (Hs), ENSMUSG00000054999 (Mm), ENSRNOG00000021000 (Rn)

UniProtKB AC

Q9UQQ1 (Hs), Q7M758 (Mm), O54697 (Rn)

EC number

3.4.17.21

N-Acetylated α-linked acidic dipeptidase 2 Show summary »« Hide summary More detailed page go icon to follow link

Comments

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References

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How to cite this family page

Database page citation:

M28: Aminopeptidase Y. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=748.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.