M12: Astacin/Adamalysin | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

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M12: Astacin/Adamalysin C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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ADAM (A Disintegrin And Metalloproteinase domain containing proteins) metalloproteinases cleave cell-surface or transmembrane proteins to generate soluble and membrane-limited products.

ADAMTS (with thrombospondin motifs) metalloproteinases cleave cell-surface or transmembrane proteins to generate soluble and membrane-limited products.

Enzymes

1669

ADAM2 Show summary »« Hide summary

Target Id	1651
Nomenclature	ADAM2
Previous and unofficial names	CT15 \| PH30β \| a disintegrin and metallopeptidase domain 2 \| A disintegrin and metalloprotease domain 2 (Fertilin beta) \| ADAM metallopeptidase domain 2 \| cancer/testis antigen 15 \| FTNB \| PH30
Genes	ADAM2 (Hs), Adam2 (Mm), Adam2 (Rn)
Ensembl ID	ENSG00000104755 (Hs), ENSMUSG00000022039 (Mm), ENSRNOG00000017027 (Rn)
UniProtKB AC	Q99965 (Hs), Q60718 (Mm), Q63202 (Rn)

ADAM7 Show summary »« Hide summary

Target Id	1655
Nomenclature	ADAM7
Previous and unofficial names	Sperm maturation-related glycoprotein GP-83 \| a disintegrin and metallopeptidase domain 7 \| ADAM metallopeptidase domain 7 \| epididymal apical protein I \| EAPI
Genes	ADAM7 (Hs), Adam7 (Mm), Adam7 (Rn)
Ensembl ID	ENSG00000069206 (Hs), ENSMUSG00000022056 (Mm), ENSRNOG00000014054 (Rn)
UniProtKB AC	Q9H2U9 (Hs), O35227 (Mm), Q63180 (Rn)

ADAM8 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1656

Nomenclature

ADAM8

Previous and unofficial names

Cell surface antigen MS2 | a disintegrin and metalloproteinase domain 8 | ADAM metallopeptidase domain 8 | CD156a

Genes

ADAM8 (Hs), Adam8 (Mm), Adam8 (Rn)

Ensembl ID

ENSG00000151651 (Hs), ENSMUSG00000025473 (Mm), ENSRNOG00000017897 (Rn)

UniProtKB AC

P78325 (Hs), Q05910 (Mm)

EC number

3.4.24.-

ADAM9 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1657

Nomenclature

ADAM9

Previous and unofficial names

Genes

ADAM9 (Hs), Adam9 (Mm), Adam9 (Rn)

Ensembl ID

ENSG00000168615 (Hs), ENSMUSG00000031555 (Mm), ENSRNOG00000017231 (Rn)

UniProtKB AC

Q13443 (Hs), Q61072 (Mm)

EC number

3.4.24.-

ADAM10 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1658

Nomenclature

ADAM10

Previous and unofficial names

Genes

ADAM10 (Hs), Adam10 (Mm), Adam10 (Rn)

Ensembl ID

ENSG00000137845 (Hs), ENSMUSG00000054693 (Mm), ENSRNOG00000054257 (Rn)

UniProtKB AC

O14672 (Hs), O35598 (Mm), Q10743 (Rn)

EC number

3.4.24.81

Selective inhibitors

GI254023X pIC₅₀ 5.3 [2]

ADAM11 Show summary »« Hide summary

ADAM12 Show summary »« Hide summary More detailed page go icon to follow link

ADAM15 Show summary »« Hide summary

Target Id	1661
Nomenclature	ADAM15
Previous and unofficial names	Metalloprotease RGD disintegrin protein \| MDC15 \| CRII-7 \| tMDCVI \| a disintegrin and metallopeptidase domain 15 (metargidin)
Genes	ADAM15 (Hs), Adam15 (Mm), Adam15 (Rn)
Ensembl ID	ENSG00000143537 (Hs), ENSMUSG00000028041 (Mm), ENSRNOG00000020590 (Rn)
UniProtKB AC	Q13444 (Hs), O88839 (Mm), Q9QYV0 (Rn)

ADAM17 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1662

Nomenclature

ADAM17

Previous and unofficial names

Genes

ADAM17 (Hs), Adam17 (Mm), Adam17 (Rn)

Ensembl ID

ENSG00000151694 (Hs), ENSMUSG00000052593 (Mm), ENSRNOG00000060694 (Rn)

UniProtKB AC

P78536 (Hs), Q9Z0F8 (Mm), Q9Z1K9 (Rn)

EC number

3.4.24.86

ADAM18 Show summary »« Hide summary

Target Id	1663
Nomenclature	ADAM18
Previous and unofficial names	ADAM27 \| Dtgn3 \| tMDCIII \| Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III, tMDC III, ADAM27
Genes	ADAM18 (Hs), Adam18 (Mm), Adam18 (Rn)
Ensembl ID	ENSG00000168619 (Hs), ENSMUSG00000031552 (Mm), ENSRNOG00000017683 (Rn)
UniProtKB AC	Q9Y3Q7 (Hs), Q9R157 (Mm), P97776 (Rn)

ADAM19 Show summary »« Hide summary

ADAM20 Show summary »« Hide summary

ADAM21 Show summary »« Hide summary

ADAM22 Show summary »« Hide summary

ADAM23 Show summary »« Hide summary

Target Id	1668
Nomenclature	ADAM23
Previous and unofficial names	Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3 \| a disintegrin and metallopeptidase domain 23 \| ADAM metallopeptidase domain 23 \| MDC3
Genes	ADAM23 (Hs), Adam23 (Mm), Adam23 (Rn)
Ensembl ID	ENSG00000114948 (Hs), ENSMUSG00000025964 (Mm), ENSRNOG00000012424 (Rn)
UniProtKB AC	O75077 (Hs), Q9R1V7 (Mm)

ADAM28 Show summary »« Hide summary

Target Id	1669
Nomenclature	ADAM28
Previous and unofficial names	eMDC II \| epididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein II \| MDC-L \| a disintegrin and metallopeptidase domain 28 \| ADAM metallopeptidase domain 28 \| Dtgn1 \| ADAM23 \| eMDCII
Genes	ADAM28 (Hs), Adam28 (Mm), Adam28 (Rn)
Ensembl ID	ENSG00000042980 (Hs), ENSMUSG00000014725 (Mm), ENSRNOG00000014518 (Rn)
UniProtKB AC	Q9UKQ2 (Hs), Q9JLN6 (Mm)

ADAM29 Show summary »« Hide summary

Target Id	1670
Nomenclature	ADAM29
Previous and unofficial names	Cancer/testis antigen 73 \| CT73 \| a disintegrin and metalloproteinase domain 29 \| svph1
Genes	ADAM29 (Hs), Adam29 (Mm)
Ensembl ID	ENSG00000168594 (Hs), ENSMUSG00000046258 (Mm)
UniProtKB AC	Q9UKF5 (Hs), Q811Q4 (Mm)

ADAM30 Show summary »« Hide summary

ADAM32 Show summary »« Hide summary

ADAM33 Show summary »« Hide summary More detailed page go icon to follow link

ADAMTS1 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1674

Nomenclature

ADAMTS1

Previous and unofficial names

C3-C5 | METH1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | ADAM metallopeptidase with thrombospondin type 1 motif | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif | ADAM metallopeptidase with thrombospondin type 1 motif 1

Genes

ADAMTS1 (Hs), Adamts1 (Mm), Adamts1 (Rn)

Ensembl ID

ENSG00000154734 (Hs), ENSMUSG00000022893 (Mm), ENSRNOG00000001607 (Rn)

UniProtKB AC

Q9UHI8 (Hs), P97857 (Mm), Q9WUQ1 (Rn)

EC number

3.4.24.-

ADAMTS2 Show summary »« Hide summary

Target Id

1675

Nomenclature

ADAMTS2

Previous and unofficial names

Genes

ADAMTS2 (Hs), Adamts2 (Mm), Adamts2 (Rn)

Ensembl ID

ENSG00000087116 (Hs), ENSMUSG00000036545 (Mm), ENSRNOG00000061484 (Rn)

UniProtKB AC

O95450 (Hs), Q8C9W3 (Mm)

EC number

3.4.24.14

ADAMTS3 Show summary »« Hide summary

Target Id	1676
Nomenclature	ADAMTS3
Previous and unofficial names	PC II-NP \| Procollagen II amino propeptide-processing enzyme \| procollagen II N-proteinase \| a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3 \| A disintegrin and metalloproteinase with thrombospondin motifs 3 \| ADAMTS-4 \| ADAM metallopeptidase with thrombospondin type 1 motif, 3 \| ADAM metallopeptidase with thrombospondin type 1 \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS3 (Hs), Adamts3 (Mm), Adamts3 (Rn)
Ensembl ID	ENSG00000156140 (Hs), ENSMUSG00000043635 (Mm), ENSRNOG00000027463 (Rn)
UniProtKB AC	O15072 (Hs)

ADAMTS4 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1677

Nomenclature

ADAMTS4

Previous and unofficial names

Genes

ADAMTS4 (Hs), Adamts4 (Mm), Adamts4 (Rn)

Ensembl ID

ENSG00000158859 (Hs), ENSMUSG00000006403 (Mm), ENSRNOG00000003538 (Rn)

UniProtKB AC

O75173 (Hs), Q8BNJ2 (Mm), Q9ESP7 (Rn)

EC number

3.4.24.82

ADAMTS5 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1678

Nomenclature

ADAMTS5

Previous and unofficial names

ADAMTS11 | ADMP-2 | aggrecanase-2 | ADAM metallopeptidase with thrombospondin type 1 motif | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif

Genes

ADAMTS5 (Hs), Adamts5 (Mm), Adamts5 (Rn)

Ensembl ID

ENSG00000154736 (Hs), ENSMUSG00000022894 (Mm), ENSRNOG00000057794 (Rn)

UniProtKB AC

Q9UNA0 (Hs), Q9R001 (Mm)

EC number

3.4.24.-

ADAMTS6 Show summary »« Hide summary

Target Id	1679
Nomenclature	ADAMTS6
Previous and unofficial names	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6 \| ADAM metallopeptidase with thrombospondin type 1 motif \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS6 (Hs), Adamts6 (Mm), Adamts6 (Rn)
Ensembl ID	ENSG00000049192 (Hs), ENSMUSG00000046169 (Mm), ENSRNOG00000012655 (Rn)
UniProtKB AC	Q9UKP5 (Hs)
Comment	Loss of function variants in ADAMTS6 have been associated with connective tissue disorders [1]. Different variants disrupt processing fibrillin-1 (FBN1) and fibrillin-2 (FBN2), or the Hippo and TGFβ signaling pathways, and cell adhesion.

ADAMTS7 Show summary »« Hide summary

Target Id

1680

Nomenclature

ADAMTS7

Previous and unofficial names

COMPase | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7 | ADAMTS7B | ADAM metallopeptidase with thrombospondin type 1 motif | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif

Genes

ADAMTS7 (Hs), Adamts7 (Mm), Adamts7 (Rn)

Ensembl ID

ENSG00000136378 (Hs), ENSMUSG00000032363 (Mm), ENSRNOG00000028036 (Rn)

UniProtKB AC

Q9UKP4 (Hs), Q68SA9 (Mm), Q1EHB3 (Rn)

Inhibitors

BAY-9835 pIC₅₀ 8.2 [3]

ADAMTS8 Show summary »« Hide summary

Target Id	1681
Nomenclature	ADAMTS8
Previous and unofficial names	METH-8 \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 \| ADAM-TS8 \| METH2 \| ADAM metallopeptidase with thrombospondin type 1 motif \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS8 (Hs), Adamts8 (Mm), Adamts8 (Rn)
Ensembl ID	ENSG00000134917 (Hs), ENSMUSG00000031994 (Mm), ENSRNOG00000005574 (Rn)
UniProtKB AC	Q9UP79 (Hs), P57110 (Mm)

ADAMTS9 Show summary »« Hide summary

Target Id	1682
Nomenclature	ADAMTS9
Previous and unofficial names	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9 \| ADAM metallopeptidase with thrombospondin type 1 motif, 9 \| ADAM metallopeptidase with thrombospondin type 1 motif \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS9 (Hs), Adamts9 (Mm), Adamts9 (Rn)
Ensembl ID	ENSG00000163638 (Hs), ENSMUSG00000030022 (Mm), ENSRNOG00000023257 (Rn)
UniProtKB AC	Q9P2N4 (Hs)

ADAMTS10 Show summary »« Hide summary

Target Id	1683
Nomenclature	ADAMTS10
Previous and unofficial names	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10 \| ZnMP \| ADAM metallopeptidase with thrombospondin type 1 motif, 10 \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10 \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS10 (Hs), Adamts10 (Mm), Adamts10 (Rn)
Ensembl ID	ENSG00000142303 (Hs), ENSMUSG00000024299 (Mm)
UniProtKB AC	Q9H324 (Hs), P58459 (Mm)

ADAMTS12 Show summary »« Hide summary

Target Id	1684
Nomenclature	ADAMTS12
Previous and unofficial names	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 \| ADAM metallopeptidase with thrombospondin type 1 motif \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS12 (Hs), Adamts12 (Mm), Adamts12 (Rn)
Ensembl ID	ENSG00000151388 (Hs), ENSMUSG00000047497 (Mm), ENSRNOG00000018865 (Rn)
UniProtKB AC	P58397 (Hs), Q811B3 (Mm)

ADAMTS13 Show summary »« Hide summary

Target Id	1685
Nomenclature	ADAMTS13
Previous and unofficial names	von Willebrand factor-cleaving protease \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 \| TTP \| VWFCP \| ADAM metallopeptidase with thrombospondin type 1 motif \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS13 (Hs), Adamts13 (Mm), Adamts13 (Rn)
Ensembl ID	ENSG00000160323 (Hs), ENSMUSG00000014852 (Mm), ENSRNOG00000005780 (Rn)
UniProtKB AC	Q76LX8 (Hs), Q769J6 (Mm)
Comment	Loss-of-function mutations in ADAMTS13 and autoimmune anti-ADAMTS13 antibodies are identified causes of thrombotic thrombocytopenic purpura (TTP). A recombinant version of ADAMTS13 (Adzynma®) was approved as an enzyme replacement therapy for patients with the congeital form of TTP in late 2023.

ADAMTS14 Show summary »« Hide summary

Target Id	1686
Nomenclature	ADAMTS14
Previous and unofficial names	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 \| TS14 \| ADAM metallopeptidase with thrombospondin type 1 motif \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS14 (Hs), Adamts14 (Mm), Adamts14 (Rn)
Ensembl ID	ENSG00000138316 (Hs), ENSMUSG00000059901 (Mm), ENSRNOG00000000563 (Rn)
UniProtKB AC	Q8WXS8 (Hs)

ADAMTS15 Show summary »« Hide summary

Target Id	1687
Nomenclature	ADAMTS15
Previous and unofficial names	A disintegrin and metalloproteinase with thrombospondin motifs 15 \| ADAM metallopeptidase with thrombospondin type 1 motif \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS15 (Hs), Adamts15 (Mm), Adamts15 (Rn)
Ensembl ID	ENSG00000166106 (Hs), ENSMUSG00000033453 (Mm), ENSRNOG00000009892 (Rn)
UniProtKB AC	Q8TE58 (Hs), P59384 (Mm)

ADAMTS16 Show summary »« Hide summary

Target Id	1688
Nomenclature	ADAMTS16
Previous and unofficial names	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16 \| ADAM metallopeptidase with thrombospondin type 1 motif \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS16 (Hs), Adamts16 (Mm), Adamts16 (Rn)
Ensembl ID	ENSG00000145536 (Hs), ENSMUSG00000049538 (Mm), ENSRNOG00000016812 (Rn)
UniProtKB AC	Q8TE57 (Hs), Q69Z28 (Mm)

ADAMTS17 Show summary »« Hide summary

Target Id	1689
Nomenclature	ADAMTS17
Previous and unofficial names	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17 \| ADAM metallopeptidase with thrombospondin type 1 motif \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17 \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS17 (Hs), Adamts17 (Mm), Adamts17 (Rn)
Ensembl ID	ENSG00000140470 (Hs), ENSMUSG00000058145 (Mm), ENSRNOG00000037080 (Rn)
UniProtKB AC	Q8TE56 (Hs)

ADAMTS18 Show summary »« Hide summary

Target Id	1690
Nomenclature	ADAMTS18
Previous and unofficial names	ADAMTS21 \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18 \| ADAM metallopeptidase with thrombospondin type 1 motif \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS18 (Hs), Adamts18 (Mm), Adamts18 (Rn)
Ensembl ID	ENSG00000140873 (Hs), ENSMUSG00000053399 (Mm), ENSRNOG00000011575 (Rn)
UniProtKB AC	Q8TE60 (Hs), Q4VC17 (Mm)

ADAMTS19 Show summary »« Hide summary

Target Id	1691
Nomenclature	ADAMTS19
Previous and unofficial names	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19 \| ADAM metallopeptidase with thrombospondin type 1 motif \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS19 (Hs), Adamts19 (Mm), Adamts19 (Rn)
Ensembl ID	ENSG00000145808 (Hs), ENSMUSG00000053441 (Mm), ENSRNOG00000019577 (Rn)
UniProtKB AC	Q8TE59 (Hs), P59509 (Mm)

ADAMTS20 Show summary »« Hide summary

Target Id	1692
Nomenclature	ADAMTS20
Previous and unofficial names	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20 \| GON-1 \| ADAM metallopeptidase with thrombospondin type 1 motif, 20 \| ADAM metallopeptidase with thrombospondin type 1 motif \| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Genes	ADAMTS20 (Hs), Adamts20 (Mm), Adamts20 (Rn)
Ensembl ID	ENSG00000173157 (Hs), ENSMUSG00000022449 (Mm), ENSRNOG00000033397 (Rn)
UniProtKB AC	P59510 (Hs), P59511 (Mm)

bone morphogenetic protein 1 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2333

Nomenclature

bone morphogenetic protein 1

Previous and unofficial names

Genes

BMP1 (Hs), Bmp1 (Mm), Bmp1 (Rn)

Ensembl ID

ENSG00000168487 (Hs), ENSMUSG00000022098 (Mm), ENSRNOG00000010890 (Rn)

UniProtKB AC

P13497 (Hs), P98063 (Mm)

EC number

3.4.24.19

Comments

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References

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1. Herrero JH, Arnaud P, Bibimbou A, Seifert DE, Mougin Z, Benarroch L, Michot C, Capri Y, Ruaud L, Dupuis-Girod S et al.. (2025) Loss of function variants in ADAMTS6: Connective tissue, Heart defect, thoracic Aortic aneurysm and Neuro developmental Syndrome (CHANS). medRxiv, Preprint. DOI: 10.1101/2025.05.02.25326573

2. Hoettecke N, Ludwig A, Foro S, Schmidt B. (2010) Improved synthesis of ADAM10 inhibitor GI254023X. Neurodegener Dis, 7 (4): 232-8. [PMID:20197648]

3. Meibom D, Wasnaire P, Beyer K, Broehl A, Cancho-Grande Y, Elowe N, Henninger K, Johannes S, Jungmann N, Krainz T et al.. (2024) BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor. J Med Chem, 67 (4): 2907-2940. [PMID:38348661]

How to cite this family page

Database page citation:

M12: Astacin/Adamalysin. Accessed on 19/06/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=739.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.