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TAAR5

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Target not currently curated in GtoImmuPdb

Target id: 170

Nomenclature: TAAR5

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 337 6q23.2 TAAR5 trace amine associated receptor 5 4
Mouse 7 337 10 A4 Taar5 trace amine-associated receptor 5
Rat 7 337 1p12 Taar5 trace amine-associated receptor 5
Previous and Unofficial Names Click here for help
PNR | Trace amine receptor 5
Database Links Click here for help
Specialist databases
GPCRdb taar5_human (Hs), taar5_mouse (Mm), taar5_rat (Rn)
Other databases
Alphafold O14804 (Hs), Q5QD14 (Mm), Q5QD23 (Rn)
ChEMBL Target CHEMBL3714046 (Hs), CHEMBL3784908 (Mm)
Ensembl Gene ENSG00000135569 (Hs), ENSMUSG00000069706 (Mm), ENSRNOG00000039869 (Rn)
Entrez Gene 9038 (Hs), 215854 (Mm), 294123 (Rn)
Human Protein Atlas ENSG00000135569 (Hs)
KEGG Gene hsa:9038 (Hs), mmu:215854 (Mm), rno:294123 (Rn)
OMIM 607405 (Hs)
Pharos O14804 (Hs)
RefSeq Nucleotide NM_003967 (Hs), NM_001009574 (Mm), NM_001009650 (Rn)
RefSeq Protein NP_003958 (Hs), NP_001009574 (Mm), NP_001009650 (Rn)
UniProtKB O14804 (Hs), Q5QD14 (Mm), Q5QD23 (Rn)
Wikipedia TAAR5 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
trimethylamine Small molecule or natural product Ligand has a PDB structure Mm Full agonist 6.5 pEC50 2
⤷ pEC50 6.5 (EC50 3x10-7 M) [2]
dimethylethylamine Small molecule or natural product Mm Full agonist 6.2 pEC50 5
⤷ pEC50 6.2 (EC50 7x10-7 M) [5]
Agonist Comments
It is reported that mTAAR5 responded to N-methylpiperidine [2]. Staubert et al. show that the agonists of murine TAAR5 do not activate intact primate and mammalian orthologs [3].
Tissue Distribution Click here for help
Skeletal muscle, amydgala, hippocampus, caudate nucleus, thalamus, hypothalamus, substantia nigra.
Species:  Human
Technique:  Northern blot
References:  4
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR
References:  2
Grueneberg ganglion (nasal septum, nasal cavity and nasal roof)
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation
References:  1
Tissue Distribution Comments
No transcripts of TAAR5 were detected by Northern blot analysis in corpus callosum, subthalamic nucleus, lung, heart, pancreas, adult liver, lymph node, bone marrow, thymus, placenta, spleen and fetal liver [4].
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R330C
Global MAF (%):  2
Subpopulation MAF (%):  AFR|AMR: 10|1
Minor allele count:  A=0.024/52
SNP accession:  VAR_055924, rs35839363
Validation:  1000 Genomes, Frequency, Cluster
Type:  Naturally occurring SNP
Species:  Human
Amino acid change:  T272M
Comment on frequency:  Low frequency (<10% in tested population)
SNP accession:  rs34746740

References

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1. Fleischer J, Schwarzenbacher K, Breer H. (2007) Expression of trace amine-associated receptors in the Grueneberg ganglion. Chem Senses, 32 (6): 623-31. [PMID:17556730]

2. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

3. Stäubert C, Böselt I, Bohnekamp J, Römpler H, Enard W, Schöneberg T. (2010) Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS ONE, 5 (6): e11133. [PMID:20559446]

4. Zeng Z, Fan P, Rand E, Kyaw H, Su K, Madike V, Carter KC, Li Y. (1998) Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain. Biochem Biophys Res Commun, 242 (3): 575-8. [PMID:9464258]

5. Zucchi R, Chiellini G, Scanlan TS, Grandy DK. (2006) Trace amine-associated receptors and their ligands. Br J Pharmacol, 149 (8): 967-78. [PMID:17088868]

Contributors

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