Quaternary Structure: Complexes

Granulocyte macrophage colony-stimulating factor receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	400	Xp22.32 and Yp11.3	CSF2RA	colony stimulating factor 2 receptor subunit alpha
Mouse	1	388	19 56.89 cM	Csf2ra	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
Rat	-	-	14	Csf2ra	colony stimulating factor 2 receptor subunit alpha

Previous and Unofficial Names

CD116 | granulocyte-macrophage colony stimulating receptor alpha | Csfgmra | CSF2R | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | colony stimulating factor 2 receptor | colony stimulating factor 2 receptor alpha subunit

Database Links
Alphafold	P15509 (Hs), Q00941 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL2364169 (Hs)
DrugBank Target	P15509 (Hs)
Ensembl Gene	ENSG00000198223 (Hs), ENSMUSG00000059326 (Mm), ENSRNOG00000049782 (Rn)
Entrez Gene	1438 (Hs), 12982 (Mm)
Human Protein Atlas	ENSG00000198223 (Hs)
KEGG Gene	hsa:1438 (Hs), mmu:12982 (Mm)
OMIM	306250 (Hs)
Pharos	P15509 (Hs)
UniProtKB	P15509 (Hs), Q00941 (Mm)
Wikipedia	CSF2RA (Hs)

Natural/Endogenous Ligands
GM-CSF {Sp: Human}

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Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference mavrilimumab Hs Binding 9.9 pIC50 1 ⤷ pIC50 9.9 (IC50 1.39x10-10 M) [1]

Immunopharmacology Comments

This is the ligand binding subunit of the functional GM-CSF receptor complex.

Immuno Process Associations

Immuno Process:  Cytokine production & signalling

Clinically-Relevant Mutations and Pathophysiology
Disease:  Surfactant metabolism dysfunction, pulmonary, 4; SMDP4 Synonyms: Congenital pulmonary alveolar proteinosis [Orphanet: ORPHA264675] Pulmonary alveolar proteinosis [Disease Ontology: DOID:12120] Disease Ontology: DOID:12120 OMIM: 300770 Orphanet: ORPHA264675