<i>TAAR8</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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TAAR8

Target not currently curated in GtoImmuPdb

Target id: 172

Nomenclature: TAAR8

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 342 6q23.2 TAAR8 trace amine associated receptor 8 3
Mouse 7 344 10 A4 Taar8a trace amine-associated receptor 8A
Rat 7 344 1p12 Taar8a trace amine associated receptor 8A
Previous and Unofficial Names
GPR102 | TAR11 | TAR5 | trace amine receptor 5 | trace amine receptor 11 | trace amine receptor 8a | trace amine associated receptor 8
Database Links
Specialist databases
GPCRDB taar8_human (Hs), taa8b_mouse (Mm), taa8a_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution
Kidney and amygdala
Species:  Human
Technique:  RT-PCR
References:  1
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation
References:  4
Intestine, spleen, testis
Species:  Mouse
Technique:  RT-PCR
References:  2
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  D328A
Global MAF (%):  5
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 5|4|2|7
Minor allele count:  C=0.049/106
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S153N
Global MAF (%):  2
Subpopulation MAF (%):  AFR: 9
Minor allele count:  A=0.020/44
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency

References

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1. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S et al.. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc. Natl. Acad. Sci. U.S.A., 98 (16): 8966-71. [PMID:11459929]

2. Chiellini G, Erba P, Carnicelli V, Manfredi C, Frascarelli S, Ghelardoni S, Mariani G, Zucchi R. (2012) Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors. J. Endocrinol., 213 (3): 223-30. [PMID:22442117]

3. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene, 275 (1): 83-91. [PMID:11574155]

4. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

Contributors

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