Top ▲

Interleukin-1 receptor-like 2

Click here for help

Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1736

Nomenclature: Interleukin-1 receptor-like 2

Family: Immunoglobulin-like family of IL-1 receptors

Quaternary Structure: Complexes
Interleukin-36 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 575 2q12.1 IL1RL2 interleukin 1 receptor like 2
Mouse 1 574 1 B Il1rl2 interleukin 1 receptor-like 2
Rat 1 561 9q22 Il1rl2 interleukin 1 receptor-like 2
Previous and Unofficial Names Click here for help
IL1RRP2 | interleukin-1 receptor-related protein 2
Database Links Click here for help
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
MAB92 Peptide Primary target of this compound Immunopharmacology Ligand Hs Antagonist 10.6 pKd 1
pKd 10.6 (Kd 2.4x10-11 M) [1]
Immunopharmacology Comments
Interleukin-1 receptor-like 2 is one of the subunits of the functional receptor for IL-36.

An antibody that mimics IL-36RA's antagonist activity at the IL-36 receptor (MAB92) has been described [1]. MAB92 inhibits proinflammatory cytokine production in primary human keratinocytes and dermal fibroblasts in vitro. Such IL-36 antagonist antibodies are predicted to present a novel therapeutic mechanism for the treatment of epithelial cell-mediated inflammation, in particular for DITRA (deficiency of IL-36 receptor antagonist) type syndromes caused by functionally inactivating mutations in IL-36RA which leave the pro-inflammatory activity of IL-36 receptor ligands unopposed.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes
GO:0004896 cytokine receptor activity ISS
GO:0004908 interleukin-1 receptor activity TAS
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0071345 cellular response to cytokine stimulus TAS
click arrow to show/hide IEA associations
GO:0004909 interleukin-1, type I, activating receptor activity IEA
GO:0032755 positive regulation of interleukin-6 production IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
GO:0050727 regulation of inflammatory response IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045582 positive regulation of T cell differentiation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045582 positive regulation of T cell differentiation IEA
GO:0050727 regulation of inflammatory response IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045582 positive regulation of T cell differentiation IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045582 positive regulation of T cell differentiation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045582 positive regulation of T cell differentiation IEA

References

Show »

1. Ganesan R, Raymond EL, Mennerich D, Woska Jr JR, Caviness G, Grimaldi C, Ahlberg J, Perez R, Roberts S, Yang D et al.. (2017) Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies. MAbs, 9 (7): 1143-1154. [PMID:28726542]

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin-1 receptor-like 2. Last modified on 08/08/2018. Accessed on 24/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1736.