Quaternary Structure: Complexes

Interleukin-36 receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	575	2q12.1	IL1RL2	interleukin 1 receptor like 2
Mouse	1	574	1 B	Il1rl2	interleukin 1 receptor-like 2
Rat	1	561	9q22	Il1rl2	interleukin 1 receptor-like 2

Previous and Unofficial Names

IL1RRP2 | interleukin-1 receptor-related protein 2

Database Links
Alphafold	Q9HB29 (Hs), Q9ERS7 (Mm), Q62929 (Rn)
CATH/Gene3D	2.60.40.10, 3.40.50.10140
ChEMBL Target	CHEMBL4665591 (Hs)
Ensembl Gene	ENSG00000115598 (Hs), ENSMUSG00000070942 (Mm), ENSRNOG00000014683 (Rn)
Entrez Gene	8808 (Hs), 107527 (Mm), 171106 (Rn)
Human Protein Atlas	ENSG00000115598 (Hs)
KEGG Gene	hsa:8808 (Hs), mmu:107527 (Mm), rno:171106 (Rn)
OMIM	604512 (Hs)
Pharos	Q9HB29 (Hs)
UniProtKB	Q9HB29 (Hs), Q9ERS7 (Mm), Q62929 (Rn)
Wikipedia	IL1RL2 (Hs)

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Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference MAB92 Hs Antagonist 10.6 pKd 2 ⤷ pKd 10.6 (Kd 2x10-11 M) [2] Description: Binding affinity for recombinant hIL-36R by SPR spesolimab Hs Binding ~10.5 pKd 1 ⤷ pKd ~10.5 (Kd ~3x10-11 M) [1]

Immunopharmacology Comments

Interleukin-1 receptor-like 2 is one of the subunits of the functional receptor for IL-36. An antibody that mimics IL-36RA's antagonist activity at the IL-36 receptor (MAB92) has been described [2]. MAB92 inhibits proinflammatory cytokine production in primary human keratinocytes and dermal fibroblasts in vitro. Such IL-36 antagonist antibodies are predicted to present a novel therapeutic mechanism for the treatment of epithelial cell-mediated inflammation, in particular for DITRA (deficiency of IL-36 receptor antagonist) type syndromes caused by functionally inactivating mutations in IL-36RA which leave the pro-inflammatory activity of IL-36 receptor ligands unopposed.