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NLRP12

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Target not currently curated in GtoImmuPdb

Target id: 1779

Nomenclature: NLRP12

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1061 19q13.42 NLRP12 NLR family pyrin domain containing 12
Mouse - 1054 7 A1 Nlrp12 NLR family, pyrin domain containing 12
Rat - - 1q12 Nlrp12 NLR family, pyrin domain containing 12
Previous and Unofficial Names Click here for help
CLR19.3 | NALP12 | PAN6 | PYPAF7 | RNO2 | NACHT, leucine rich repeat and PYD containing 12 | Monarch1 | FCAS2 | RNO | NLR family, pyrin domain containing 12 | NLR family
Database Links Click here for help
Alphafold
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0050728 negative regulation of inflammatory response IMP
GO:0050729 positive regulation of inflammatory response NAS
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GO:0036336 dendritic cell migration IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0050728 negative regulation of inflammatory response IMP
GO:0050729 positive regulation of inflammatory response NAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes
GO:0001818 negative regulation of cytokine production IDA
GO:0032661 regulation of interleukin-18 production NAS
GO:0032692 negative regulation of interleukin-1 production IDA
GO:0032715 negative regulation of interleukin-6 production IDA
GO:0032731 positive regulation of interleukin-1 beta production NAS
GO:0071345 cellular response to cytokine stimulus IBA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0036336 dendritic cell migration IEA
Physiological Functions Comments
Involved in inflammasome formation, bacterial control and inflammatory migration.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Dermatitis
Description: Includes atopic, seborrhoeic, and contact dermatitis.
Disease Ontology: DOID:2723
Disease:  Familial cold autoinflammatory syndrome 2; FCAS2
Synonyms: NLRP12-associated hereditary periodic fever syndrome [Orphanet: ORPHA247868]
OMIM: 611762
Orphanet: ORPHA247868

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