anti-Mullerian hormone receptor type 2

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Targets
Catalytic receptors
Receptor kinases
TKL: Tyrosine kinase-like
Receptor serine/threonine kinase (RSTK) family
Type II receptor serine/threonine kinases
anti-Mullerian hormone receptor type 2

Target not currently curated in GtoImmuPdb

Target id: 1793

Nomenclature: anti-Mullerian hormone receptor type 2

Abbreviated Name: MISR2

Family: Type II receptor serine/threonine kinases

Quaternary Structure: Complexes
Anti-Müllerian hormone receptors

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	573	12q13.13	AMHR2	anti-Mullerian hormone receptor type 2
Mouse	1	568	15 57.58 cM	Amhr2	anti-Mullerian hormone type 2 receptor
Rat	1	557	7q36	Amhr2	anti-Mullerian hormone receptor type 2

Previous and Unofficial Names
AMH type II receptor \| anti-Mullerian hormone type 2 receptor \| MIS type II receptor \| MISIIR \| MISR2 \| anti-Mullerian hormone receptor type II \| anti-Mullerian hormone receptor

Database Links
Alphafold	Q16671 (Hs), Q8K592 (Mm), Q62893 (Rn)
BRENDA	2.7.11.30
Ensembl Gene	ENSG00000135409 (Hs), ENSMUSG00000023047 (Mm), ENSRNOG00000014850 (Rn)
Entrez Gene	269 (Hs), 110542 (Mm), 29530 (Rn)
Human Protein Atlas	ENSG00000135409 (Hs)
KEGG Enzyme	2.7.11.30
KEGG Gene	hsa:269 (Hs), mmu:110542 (Mm), rno:29530 (Rn)
OMIM	600956 (Hs)
Orphanet	ORPHA119660 (Hs)
Pharos	Q16671 (Hs)
RefSeq Nucleotide	NM_001164690 (Hs), NM_144547 (Mm), NM_030998 (Rn)
RefSeq Protein	NP_001158162 (Hs), NP_653130 (Mm), NP_112260 (Rn)
UniProtKB	Q16671 (Hs), Q8K592 (Mm), Q62893 (Rn)
Wikipedia	AMHR2 (Hs)

Enzyme Reaction

EC Number: 2.7.11.30

Natural/Endogenous Ligands
Müllerian inhibiting substance {Sp: Human}

Phenotypes, Alleles and Disease Models

Mouse data from MGI

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Allele	Composition & genetic background	Accession	Phenotype Id	Phenotype	Reference
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0004256	abnormal maternal decidual layer morphology	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Ar^tm1Chc	Amhr2^tm3(cre)Bhr/Amhr2⁺,Ar^tm1Chc/Y involves: 129S/SvEv * C57BL/6	MGI:105062 MGI:88064	MP:0001930	abnormal meiosis	PMID: 17142319
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0008256	abnormal myometrium morphology	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0001928	abnormal ovulation	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0001712	abnormal placenta development	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0008803	abnormal placental labyrinth vasculature morphology	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Ar^tm1Chc	Amhr2^tm3(cre)Bhr/Amhr2⁺,Ar^tm1Chc/Y involves: 129S/SvEv * C57BL/6	MGI:105062 MGI:88064	MP:0002216	abnormal seminiferous tubule morphology	PMID: 17142319
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0002216	abnormal seminiferous tubule morphology	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0008959	abnormal spongiotrophoblast cell morphology	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0004244	abnormal spontaneous abortion rate	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0006418	abnormal testis cord formation	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0003830	abnormal testis development	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0004014	abnormal uterine environment	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0001134	absent corpus luteum	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0003403	absent placental labyrinth	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0003379	absent sexual maturation	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Ar^tm1Chc	Amhr2^tm3(cre)Bhr/Amhr2⁺,Ar^tm1Chc/Y involves: 129S/SvEv * C57BL/6	MGI:105062 MGI:88064	MP:0008261	arrest of male meiosis	PMID: 17142319
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Ar^tm1Chc	Amhr2^tm3(cre)Bhr/Amhr2⁺,Ar^tm1Chc/Y involves: 129S/SvEv * C57BL/6	MGI:105062 MGI:88064	MP:0001155	arrest of spermatogenesis	PMID: 17142319
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0001155	arrest of spermatogenesis	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Ar^tm1Chc	Amhr2^tm3(cre)Bhr/Amhr2⁺,Ar^tm1Chc/Y involves: 129S/SvEv * C57BL/6	MGI:105062 MGI:88064	MP:0005159	azoospermia	PMID: 17142319
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0002286	cryptorchism	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Ar^tm1Chc	Amhr2^tm3(cre)Bhr/Amhr2⁺,Ar^tm1Chc/Y involves: 129S/SvEv * C57BL/6	MGI:105062 MGI:88064	MP:0002780	decreased circulating testosterone level	PMID: 17142319
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0002780	decreased circulating testosterone level	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0002682	decreased mature ovarian follicle number	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0001785	edema	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0008762	embryonic lethality	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0001926	female infertility	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0001914	hemorrhage	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0001729	impaired embryo implantation	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0009397	increased trophoblast giant cell number	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0009207	internal male genitalia hypoplasia	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Ar^tm1Chc	Amhr2^tm3(cre)Bhr/Amhr2⁺,Ar^tm1Chc/Y involves: 129S/SvEv * C57BL/6	MGI:105062 MGI:88064	MP:0001925	male infertility	PMID: 17142319
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0001925	male infertility	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0009444	ovarian follicular cyst	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0004834	ovary hemorrhage	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0005158	ovary hypoplasia	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0001923	reduced female fertility	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr2f2^tm2.1Tsa	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa involves: 129S7/SvEvBrd	MGI:105062 MGI:1352452	MP:0009089	short uterine horn	PMID: 17404209
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0002768	small adrenal glands	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Ar^tm1Chc	Amhr2^tm3(cre)Bhr/Amhr2⁺,Ar^tm1Chc/Y involves: 129S/SvEv * C57BL/6	MGI:105062 MGI:88064	MP:0001153	small seminiferous tubules	PMID: 17142319
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Ar^tm1Chc	Amhr2^tm3(cre)Bhr/Amhr2⁺,Ar^tm1Chc/Y involves: 129S/SvEv * C57BL/6	MGI:105062 MGI:88064	MP:0001147	small testis	PMID: 17142319
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0001147	small testis	PMID: 15118069
Amhr2⁺\|Amhr2^tm3(cre)Bhr\|Nr5a1^tm1Klp\|Nr5a1^tm2Klp	Amhr2^tm3(cre)Bhr/Amhr2⁺,Nr5a1^tm1Klp/Nr5a1^tm2Klp involves: 129P2/OlaHsd	MGI:105062 MGI:1346833	MP:0001940	testicular hypoplasia	PMID: 15118069