tumor necrosis factor receptor 1 | Tumour necrosis factor (TNF) receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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tumor necrosis factor receptor 1

target has curated data in GtoImmuPdb

Target id: 1870

Nomenclature: tumor necrosis factor receptor 1

Abbreviated Name: TNFR1

Systematic Nomenclature: TNFRSF1A

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 455 12p13.31 TNFRSF1A TNF receptor superfamily member 1A
Mouse 1 454 Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a
Rat 1 461 Tnfrsf1a TNF receptor superfamily member 1A
Previous and Unofficial Names
CD120a | p55TNFR | TNFAR | TNF-R1 | TNF-R55 | tumor necrosis factor receptor superfamily, member 1A | tumor necrosis factor receptor superfamily
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Natural/Endogenous Ligands
lymphotoxin-α {Sp: Human}
tumour necrosis factor membrane form {Sp: Human}
tumour necrosis factor shed form {Sp: Human}
Adaptor proteins (Human)
TRADD
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
lymphotoxin-α {Sp: Human} Hs - - -
tumour necrosis factor membrane form {Sp: Human} Hs - - -
tumour necrosis factor shed form {Sp: Human} Hs - - -
Immunopharmacology Comments
We have included TNFR1 in GtoImmuPdb based on it being a receptor for lymphotoxin-α, a cytotoxic protein performing a variety of important roles in immune system development and regulation [1-2].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0006954 inflammatory response ISS
GO:0050728 negative regulation of inflammatory response IMP
GO:0050729 positive regulation of inflammatory response ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0050728 negative regulation of inflammatory response IMP
GO:0050729 positive regulation of inflammatory response ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0005031 tumor necrosis factor-activated receptor activity IBA
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
GO:0019221 cytokine-mediated signaling pathway ISS
GO:0033209 tumor necrosis factor-mediated signaling pathway IMP

References

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1. Gubernatorova EO, Tumanov AV. (2016) Tumor Necrosis Factor and Lymphotoxin in Regulation of Intestinal Inflammation. Biochemistry Mosc., 81 (11): 1309-1325. [PMID:27914457]

2. Ngo VN, Korner H, Gunn MD, Schmidt KN, Riminton DS, Cooper MD, Browning JL, Sedgwick JD, Cyster JG. (1999) Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med., 189 (2): 403-12. [PMID:9892622]

Contributors

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