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target has curated data in GtoImmuPdb
Target id: 1877
Nomenclature: CD30
Systematic Nomenclature: TNFRSF8
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 595 | 1p36.22 | TNFRSF8 | TNF receptor superfamily member 8 | |
Mouse | 1 | 498 | 4 78.17 cM | Tnfrsf8 | tumor necrosis factor receptor superfamily, member 8 | |
Rat | 1 | 492 | 5q36 | Tnfrsf8 | TNF receptor superfamily member 8 |
Previous and Unofficial Names |
CD30L receptor | tumor necrosis factor receptor superfamily, member 8 | tumor necrosis factor receptor superfamily |
Database Links | |
Alphafold | P28908 (Hs), Q60846 (Mm), P97525 (Rn) |
ChEMBL Target | CHEMBL2364161 (Hs) |
DrugBank Target | P28908 (Hs) |
Ensembl Gene | ENSG00000120949 (Hs), ENSMUSG00000028602 (Mm), ENSRNOG00000016782 (Rn) |
Entrez Gene | 943 (Hs), 21941 (Mm), 25069 (Rn) |
Human Protein Atlas | ENSG00000120949 (Hs) |
KEGG Gene | hsa:943 (Hs), mmu:21941 (Mm), rno:25069 (Rn) |
OMIM | 153243 (Hs) |
Pharos | P28908 (Hs) |
UniProtKB | P28908 (Hs), Q60846 (Mm), P97525 (Rn) |
Wikipedia | TNFRSF8 (Hs) |
Natural/Endogenous Ligands |
CD30 ligand {Sp: Human} |
Adaptor proteins (Human) |
TRAF1, TRAF2, TRAF3, TRAF5 |
Download all structure-activity data for this target as a CSV file
Antibodies | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Other Binding Ligands | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
Expressed by activated T and B cells. Interacts with TRAF2 and TRAF5 to elicit downstream signalling events (NF-κB activation). CD30 may protect against autoimmunity by limiting the proliferative potential of autoreactive CD8 effector T cells. CD30 is the target of the approved anti-lymphoma monoclonal antibody drug brentuximab vedotin. |
Cell Type Associations | ||||
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Immuno Process Associations | ||
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