BAFF receptor | Tumour necrosis factor (TNF) receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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BAFF receptor

target has curated data in GtoImmuPdb

Target id: 1886

Nomenclature: BAFF receptor

Abbreviated Name: BAFF-R

Systematic Nomenclature: TNFRSF13C

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 184 22q13.2 TNFRSF13C TNF receptor superfamily member 13C
Mouse 1 175 Tnfrsf13c tumor necrosis factor receptor superfamily, member 13c
Rat - - Tnfrsf13c TNF receptor superfamily member 13C
Previous and Unofficial Names
B cell-activating factor receptor | tumor necrosis factor receptor superfamily, member 13c | BAFFR | Bcmd1 | CD268 | tumor necrosis factor receptor superfamily, member 13C | tumor necrosis factor receptor superfamily member 13C | tumor necrosis factor receptor superfamily
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Natural/Endogenous Ligands
BAFF {Sp: Human}
Adaptor proteins (Human)
TRAF3

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Antibodies
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Antibody Sp. Action Value Parameter Reference
ianalumab Hs Antagonist 10.7 pIC50 1
pIC50 10.7 (IC50 1.9x10-11 M) [1]
Description: Inhibition of BAFFR-BLyS binding by the whole Ig mAb.
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
BAFF {Sp: Human} Hs - - -
Immunopharmacology Comments
This is a type III membrane bound receptor for B cell activating factor (BAFF). BAFF enhances B cell survival and hence regulates the peripheral B cell population. It is suggested that overproduction of BAFF may enhance the survival of autoreactive B cells, an effect which may contribute in the pathogenesis of autoimmune diseases. The anti-BAFF receptor monoclonal antibody ianalumab (VAY736; Novartis) has progressed to clinical evaluation in autoimmune conditions and B cell malignancies.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
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GO:0045078 positive regulation of interferon-gamma biosynthetic process IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 4 GO processes, IEA only
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GO:0002250 adaptive immune response IEA
GO:0002636 positive regulation of germinal center formation IEA
GO:0031295 T cell costimulation IEA
GO:0042102 positive regulation of T cell proliferation IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 4 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
GO:0002636 positive regulation of germinal center formation IEA
GO:0030890 positive regulation of B cell proliferation IEA
GO:0031296 B cell costimulation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 7 GO processes, IEA only
GO:0050776 regulation of immune response IMP
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GO:0001782 B cell homeostasis IEA
GO:0002636 positive regulation of germinal center formation IEA
GO:0030890 positive regulation of B cell proliferation IEA
GO:0031295 T cell costimulation IEA
GO:0031296 B cell costimulation IEA
GO:0042102 positive regulation of T cell proliferation IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0031295 T cell costimulation IEA
GO:0042102 positive regulation of T cell proliferation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0030890 positive regulation of B cell proliferation IEA
GO:0031295 T cell costimulation IEA
GO:0031296 B cell costimulation IEA
GO:0042102 positive regulation of T cell proliferation IEA
Immuno Disease Associations
Disease Name:  Sjögren's syndrome
Disease Synonyms:  no synonynms
Comment:  Molecular target for SS- see NCT02962895 which is designed to evaluate clinical efficacy of anti-BAFF-R mAb VAY736 in SS patients.
Disease X-refs:  Orphanet: ORPHA378
References: 
Disease Name:  Rheumatoid arthritis
Disease Synonyms:  no synonynms
Comment:  Molecular target for RA- see NCT02675803 which was designed to evaluate clinical efficacy of anti-BAFF-R mAb VAY736 in RA patients.
Disease X-refs:  Disease Ontology: DOID:7148
OMIM: 180300
References: 
Disease Name:  Multiple sclerosis
Disease Synonyms:  no synonynms
Comment:  The anti-BAFF-R mAb VAY736 has completed Phase 2 clinical evaluation in RRMS- see NCT02038049.
Disease X-refs:  Disease Ontology: DOID:2377
OMIM: 126200
Orphanet: ORPHA802
References:  2

References

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1. Heusser C, Neugebauer J, Schaadt E, Urlinger S, Woisetschlaeger M. (2010) Compositions and methods of use for therapeutic antibodies. Patent number: WO2010007082A1. Assignee: Novartis. Priority date: 17/07/2008. Publication date: 21/01/2010.

2. Rahmanzadeh R, Weber MS, Brück W, Navardi S, Sahraian MA. (2018) B cells in multiple sclerosis therapy-A comprehensive review. Acta Neurol. Scand., 137 (6): 544-556. [PMID:29512131]

Contributors

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