Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	184	22q13.2	TNFRSF13C	TNF receptor superfamily member 13C
Mouse	1	175	15 E1	Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c
Rat	-	-		Tnfrsf13c	TNF receptor superfamily member 13C

Previous and Unofficial Names

B cell-activating factor receptor | tumor necrosis factor receptor superfamily, member 13c | BAFFR | Bcmd1 | CD268 | tumor necrosis factor receptor superfamily, member 13C | tumor necrosis factor receptor superfamily member 13C | tumor necrosis factor receptor superfamily

Database Links
Alphafold	Q96RJ3 (Hs), Q9D8D0 (Mm)
ChEMBL Target	CHEMBL4630882 (Hs)
Ensembl Gene	ENSG00000159958 (Hs), ENSMUSG00000068105 (Mm), ENSRNOG00000007664 (Rn)
Entrez Gene	115650 (Hs), 72049 (Mm), 500910 (Rn)
Human Protein Atlas	ENSG00000159958 (Hs)
KEGG Gene	hsa:115650 (Hs), mmu:72049 (Mm), rno:500910 (Rn)
OMIM	606269 (Hs)
Pharos	Q96RJ3 (Hs)
UniProtKB	Q96RJ3 (Hs), Q9D8D0 (Mm)
Wikipedia	TNFRSF13C (Hs)

Natural/Endogenous Ligands
BAFF {Sp: Human}

Adaptor proteins (Human)

TRAF3

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference ianalumab Hs Antagonist 10.7 pIC50 1 ⤷ pIC50 10.7 (IC50 1.9x10-11 M) [1] Description: Inhibition of BAFFR-BLyS binding by the whole Ig mAb.

Other Binding Ligands
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference BAFF {Sp: Human} Hs - - - ⤷

Immunopharmacology Comments

This is a type III membrane bound receptor for B cell activating factor (BAFF). BAFF enhances B cell survival and hence regulates the peripheral B cell population. It is suggested that overproduction of BAFF may enhance the survival of autoreactive B cells, an effect which may contribute in the pathogenesis of autoimmune diseases. The anti-BAFF receptor monoclonal antibody ianalumab (VAY736; Novartis) has progressed to clinical evaluation in autoimmune conditions and B cell malignancies.

Immuno Process Associations

Immuno Process:  Cytokine production & signalling

Immuno Process:  T cell (activation)

Immuno Process:  B cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Chemotaxis & migration

Immuno Process:  Cellular signalling

Immuno Disease Associations

Disease Name:  Sjögren's syndrome Disease Synonyms:  no synonynms Comment:  Molecular target for SS- see NCT02962895 which is designed to evaluate clinical efficacy of anti-BAFF-R mAb VAY736 in SS patients. Disease X-refs:  Orphanet: ORPHA378 References:

Disease Name:  Rheumatoid arthritis Disease Synonyms:  no synonynms Comment:  Molecular target for RA- see NCT02675803 which was designed to evaluate clinical efficacy of anti-BAFF-R mAb VAY736 in RA patients. Disease X-refs:  Disease Ontology: DOID:7148 OMIM: 180300 References:

Disease Name:  Multiple sclerosis Disease Synonyms:  no synonynms Comment:  The anti-BAFF-R mAb VAY736 has completed Phase 2 clinical evaluation in RRMS- see NCT02038049. Disease X-refs:  Disease Ontology: DOID:2377 OMIM: 126200 Orphanet: ORPHA802 References:  2