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Interferon-α/β receptor

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1898

Nomenclature: Interferon-α/β receptor

Family: Interferon receptor family

Contents:

Quaternary Structure: Subunits
interferon α/β receptor 1 (Ligand-binding subunit)
Interferon α/β receptor 2 (Other subunit)
Previous and Unofficial Names Click here for help
Interferon-α/β 1/2 heteromer
Natural/Endogenous Ligands Click here for help
IFN-α1/13 {Sp: Human}
IFN-α10 {Sp: Human}
IFN-α14 {Sp: Human}
IFN-α16 {Sp: Human}
IFN-α17 {Sp: Human}
IFN-α2 {Sp: Human}
IFN-α21 {Sp: Human}
IFN-α4 {Sp: Human}
IFN-α5 {Sp: Human}
IFN-α6 {Sp: Human}
IFN-α7 {Sp: Human}
IFN-α8 {Sp: Human}
IFN-β {Sp: Human}
IFN-κ {Sp: Human}
IFN-ω {Sp: Human}

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Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IFN-α1/13 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-α10 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-α14 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-α16 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-α17 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-α2 {Sp: Human} Peptide Approved drug Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-α21 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-α4 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-α5 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-α6 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-α7 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-α8 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-β {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-κ {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
IFN-ω {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
⤷
peginterferon alfa-2b Peptide Approved drug Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Agonist - - 1
⤷ [1]
Immunopharmacology Comments
The interferon-α/β receptor has multiple endogenous ligands, including a number IFN-αs, and interferons β, κ and ω. The functional receptor is a heterodimer of interferon α/β receptor 1 and interferon α/β receptor 2.

References

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1. Ward AC, Touw I, Yoshimura A. (2000) The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood, 95 (1): 19-29. [PMID:10607680]

How to cite this page

Interferon receptor family: Interferon-α/β receptor. Last modified on 10/04/2017. Accessed on 19/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1898.