Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	795	1p36.33	CDK11B	cyclin dependent kinase 11B
Mouse	-	784	4 86.73 cM	Cdk11b	cyclin dependent kinase 11B
Rat	-	436	5q36	Cdk11b	cyclin-dependent kinase 11B

Previous and Unofficial Names

CDC2L1 | CDK11-p110 | CDK11-p46 | CDK11-p58 | cell division cycle 2-like protein kinase 1 | cell division protein kinase 11 | PITSLRE serine/threonine-protein kinase CDC2L1 | PITSLRE serine/threonine-protein kinase CDC2L1CDK11-p110

Database Links
Alphafold	P21127 (Hs), P24788 (Mm), P46892 (Rn)
BRENDA	2.7.11.22
ChEMBL Target	CHEMBL5808 (Hs)
Ensembl Gene	ENSG00000248333 (Hs), ENSMUSG00000029062 (Mm), ENSRNOG00000017213 (Rn)
Entrez Gene	984 (Hs), 12537 (Mm), 252879 (Rn)
Human Protein Atlas	ENSG00000248333 (Hs)
KEGG Enzyme	2.7.11.22
KEGG Gene	hsa:984 (Hs), mmu:12537 (Mm), rno:252879 (Rn)
OMIM	176873 (Hs)
Pharos	P21127 (Hs)
RefSeq Nucleotide	NM_033486 (Hs), NM_007661 (Mm), NM_145766 (Rn)
RefSeq Protein	NP_277021 (Hs), NP_031687 (Mm), NP_665709 (Rn)
UniProtKB	P21127 (Hs), P24788 (Mm), P46892 (Rn)
Wikipedia	CDK11B (Hs)

Enzyme Reaction
EC Number: 2.7.11.22

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: CDC2L1
Ligand Sp. Type Action Value Parameter AT-7519 Hs Inhibitor Inhibition 8.1 pKd BMS-387032 Hs Inhibitor Inhibition 7.0 pKd tozasertib Hs Inhibitor Inhibition 6.5 pKd BMS-345541 Hs Inhibitor Inhibition 6.4 pKd foretinib Hs Inhibitor Inhibition 6.2 pKd crizotinib Hs Inhibitor Inhibition 6.1 pKd barasertib-hQPA Hs Inhibitor Inhibition 5.9 pKd linifanib Hs Inhibitor Inhibition 5.9 pKd AST-487 Hs Inhibitor Inhibition 5.8 pKd pazopanib Hs Inhibitor Inhibition 5.7 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »