Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	725	16p12.2	EEF2K	eukaryotic elongation factor 2 kinase
Mouse	-	724	7 F2	Eef2k	eukaryotic elongation factor-2 kinase
Rat	-	724	1q36	Eef2k	eukaryotic elongation factor-2 kinase

Previous and Unofficial Names

SMEF2K

Database Links
Alphafold	O00418 (Hs), O08796 (Mm), P70531 (Rn)
BRENDA	2.7.11.20
ChEMBL Target	CHEMBL5026 (Hs), CHEMBL3325307 (Rn)
Ensembl Gene	ENSG00000103319 (Hs), ENSMUSG00000035064 (Mm), ENSRNOG00000016448 (Rn)
Entrez Gene	29904 (Hs), 13631 (Mm), 25435 (Rn)
Human Protein Atlas	ENSG00000103319 (Hs)
KEGG Enzyme	2.7.11.20
KEGG Gene	hsa:29904 (Hs), mmu:13631 (Mm), rno:25435 (Rn)
OMIM	606968 (Hs)
Pharos	O00418 (Hs)
RefSeq Nucleotide	NM_013302 (Hs), NM_007908 (Mm), NM_012947 (Rn)
RefSeq Protein	NP_037434 (Hs), NP_031934 (Mm), NP_037079 (Rn)
UniProtKB	O00418 (Hs), O08796 (Mm), P70531 (Rn)
Wikipedia	EEF2K (Hs)

Enzyme Reaction
EC Number: 2.7.11.20

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 34 [PMID: 20189382] Hs Inhibition 6.8 pIC50 2 ⤷ pIC50 6.8 (IC50 1.7x10-7 M) [2]

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1...
Key to terms and symbols		Click column headers to sort
Target used in screen: eEF-2K/nd
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM Rho kinase inhibitor IV Hs Inhibitor Inhibition 72.0 113.0 IKK-2 inhibitor IV Hs Inhibitor Inhibition 77.0 38.0 isogranulatimide Hs Inhibitor Inhibition 78.0 59.0 PKR inhibitor Hs Inhibitor Inhibition 79.0 97.0 SU11274 Hs Inhibitor Inhibition 79.0 132.0 PP3 Hs Inhibitor Inhibition 81.0 72.0 JAK inhibitor I Hs Inhibitor Inhibition 81.0 126.0 MEK1/2 inhibitor Hs Inhibitor Inhibition 81.0 82.0 AG 1296 Hs Inhibitor Inhibition 82.0 101.0 Cdk1/5 inhibitor Hs Inhibitor Inhibition 82.0 110.0
Displaying the top 10 most potent ligands  View all ligands in screen »

Immuno Process Associations

Immuno Process:  Antigen presentation