Top ▲

integrin linked kinase

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2041

Nomenclature: integrin linked kinase

Abbreviated Name: ILK

Family: ILK subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 452 11p15.4 ILK integrin linked kinase
Mouse - 452 7 E1 Ilk integrin linked kinase
Rat - 452 1 q33 Ilk integrin-linked kinase
Previous and Unofficial Names Click here for help
ILK1 | ILK2 | p59ILK | integrin-linked kinase
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain
PDB Id:  3F6Q
Resolution:  1.6Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 22 [PMID: 21823616] Small molecule or natural product Primary target of this compound Hs Inhibition 6.2 pIC50 2
pIC50 6.2 (IC50 6x10-7 M) [2]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0033209 tumor necrosis factor-mediated signaling pathway IMP

References

Show »

1. Chiswell BP, Zhang R, Murphy JW, Boggon TJ, Calderwood DA. (2008) The structural basis of integrin-linked kinase-PINCH interactions. Proc. Natl. Acad. Sci. U.S.A., 105 (52): 20677-82. [PMID:19074270]

2. Lee SL, Hsu EC, Chou CC, Chuang HC, Bai LY, Kulp SK, Chen CS. (2011) Identification and characterization of a novel integrin-linked kinase inhibitor. J. Med. Chem., 54 (18): 6364-74. [PMID:21823616]

How to cite this page

ILK subfamily: integrin linked kinase. Last modified on 29/01/2016. Accessed on 24/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2041.