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integrin linked kinase

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Target not currently curated in GtoImmuPdb

Target id: 2041

Nomenclature: integrin linked kinase

Abbreviated Name: ILK

Family: ILK subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 452 11p15.4 ILK integrin linked kinase
Mouse - 452 7 E3 Ilk integrin linked kinase
Rat - 452 1q32 Ilk integrin-linked kinase
Previous and Unofficial Names Click here for help
ILK1 | ILK2 | p59ILK | integrin-linked kinase
Database Links Click here for help
Alphafold Q13418 (Hs), O55222 (Mm), Q99J82 (Rn)
BRENDA 2.7.11.1
CATH/Gene3D 1.25.40.20
ChEMBL Target CHEMBL5247 (Hs)
Ensembl Gene ENSG00000166333 (Hs), ENSMUSG00000030890 (Mm), ENSRNOG00000018993 (Rn)
Entrez Gene 3611 (Hs), 16202 (Mm), 170922 (Rn)
Human Protein Atlas ENSG00000166333 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:3611 (Hs), mmu:16202 (Mm), rno:170922 (Rn)
OMIM 602366 (Hs)
Pharos Q13418 (Hs)
RefSeq Nucleotide NM_001014794 (Hs), NM_001161724 (Mm), NM_133409 (Rn)
RefSeq Protein NP_001014794 (Hs), NP_001155196 (Mm), NP_596900 (Rn)
UniProtKB Q13418 (Hs), O55222 (Mm), Q99J82 (Rn)
Wikipedia ILK (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain
PDB Id:  3F6Q
Resolution:  1.6Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 22 [PMID: 21823616] Small molecule or natural product Primary target of this compound Hs Inhibition 6.2 pIC50 2
⤷ pIC50 6.2 (IC50 6x10-7 M) [2]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling

References

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1. Chiswell BP, Zhang R, Murphy JW, Boggon TJ, Calderwood DA. (2008) The structural basis of integrin-linked kinase-PINCH interactions. Proc Natl Acad Sci USA, 105 (52): 20677-82. [PMID:19074270]

2. Lee SL, Hsu EC, Chou CC, Chuang HC, Bai LY, Kulp SK, Chen CS. (2011) Identification and characterization of a novel integrin-linked kinase inhibitor. J Med Chem, 54 (18): 6364-74. [PMID:21823616]

How to cite this page

ILK subfamily: integrin linked kinase. Last modified on 29/01/2016. Accessed on 05/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2041.