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kinase suppressor of ras 2

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Target not currently curated in GtoImmuPdb

Target id: 2052

Nomenclature: kinase suppressor of ras 2

Abbreviated Name: KSR2

Family: RAF family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 950 12q24.22-q24.23 KSR2 kinase suppressor of ras 2
Mouse - 960 5 F Ksr2 kinase suppressor of ras 2
Rat - - 12q16 Ksr2 kinase suppressor of ras 2
Database Links Click here for help
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  KSR2-MEK1 HETERODIMER
PDB Id:  2Y4I
Resolution:  3.46Å
Species:  Human
References:  1

References

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1. Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D. (2011) A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature, 472 (7343): 366-9. [PMID:21441910]

How to cite this page

RAF family: kinase suppressor of ras 2. Last modified on 18/08/2014. Accessed on 21/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2052.