Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	322	8p21.1	PBK	PDZ binding kinase
Mouse	-	330	14 34.36 cM	Pbk	PDZ binding kinase
Rat	-	337	15p12	Pbk	PDZ binding kinase

Previous and Unofficial Names

Spermatogenesis-related protein kinase | T-LAK cell-originated protein kinase | SPK | TOPK | cancer/testis antigen 84 ( CT84 ) | T-lymphokine-activated killer cell-originated protein kinase

Database Links
Alphafold	Q96KB5 (Hs), Q9JJ78 (Mm)
BRENDA	2.7.12.2
ChEMBL Target	CHEMBL4896 (Hs)
Ensembl Gene	ENSG00000168078 (Hs), ENSMUSG00000022033 (Mm), ENSRNOG00000015308 (Rn)
Entrez Gene	55872 (Hs), 52033 (Mm), 290326 (Rn)
Human Protein Atlas	ENSG00000168078 (Hs)
KEGG Enzyme	2.7.12.2
KEGG Gene	hsa:55872 (Hs), mmu:52033 (Mm), rno:290326 (Rn)
OMIM	611210 (Hs)
Pharos	Q96KB5 (Hs)
RefSeq Nucleotide	NM_018492 (Hs), NM_023209 (Mm), NM_001079937 (Rn)
RefSeq Protein	NP_060962 (Hs), NP_075698 (Mm), NP_001073406 (Rn)
UniProtKB	Q96KB5 (Hs), Q9JJ78 (Mm)
Wikipedia	PBK (Hs)

Enzyme Reaction
EC Number: 2.7.12.2

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference OTS964 Hs Inhibition 7.6 pIC50 2 ⤷ pIC50 7.6 (IC50 2.8x10-8 M) [2]

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/PBK(TOPK)
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM K-252a Hs Inhibitor Inhibition 2.7 staurosporine Hs Inhibitor Inhibition 27.8 JAK inhibitor I Hs Inhibitor Inhibition 39.1 SB 218078 Hs Inhibitor Inhibition 39.9 Y27632 Hs Inhibitor Inhibition 56.7 GSK-3beta inhibitor II Hs Inhibitor Inhibition 62.7 PDK1/Akt/Flt dual pathway inhibitor Hs Inhibitor Inhibition 64.5 VEGF receptor tyrosine kinase inhibitor III Hs Inhibitor Inhibition 66.2 Syk inhibitor II Hs Inhibitor Inhibition 66.4 PKR inhibitor Hs Inhibitor Inhibition 67.4
Displaying the top 10 most potent ligands  View all ligands in screen »

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation