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phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

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Target not currently curated in GtoImmuPdb

Target id: 2150

Nomenclature: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Abbreviated Name: C2α/PIK3C2A

Family: Phosphatidylinositol-4-phosphate 3-kinase family, Phosphatidylinositol kinases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1686 11p15.1 PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Mouse - 1686 7 61.62 cM Pik3c2a phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Rat - 1687 1 q34-q35 Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Previous and Unofficial Names Click here for help
Phosphoinositide 3-kinase-C2-alpha | phosphoinositide-3-kinase, class 2, alpha polypeptide | PI3KC2 | PI3K-C2alpha | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | phosphatidylinositol-4-phosphate 3-kinase
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated with ligand binding.
PDB Id:  2RED
Resolution:  2.1Å
Species:  Human
References:  2
Enzyme Reaction Click here for help
EC Number: 2.7.1.154

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
torin 2 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.6 pIC50 1
pIC50 7.6 (IC50 2.81x10-8 M) [1]
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0006897 endocytosis IMP

References

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1. Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Ahmed T, Sabatini DM, Gray NS. (2011) Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J Med Chem, 54 (5): 1473-80. [PMID:21322566]

2. Parkinson GN, Vines D, Driscoll PC, Djordjevic S. (2008) Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding. BMC Struct Biol, 8: 13. [PMID:18312637]

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