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phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

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Target not currently curated in GtoImmuPdb

Target id: 2150

Nomenclature: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Abbreviated Name: C2α/PIK3C2A

Family: Phosphatidylinositol-4-phosphate 3-kinase family, Phosphatidylinositol kinases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1686 11p15.1 PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Mouse - 1686 7 61.62 cM Pik3c2a phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Rat - 1687 1 q34-q35 Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Previous and Unofficial Names Click here for help
Phosphoinositide 3-kinase-C2-alpha | phosphoinositide-3-kinase, class 2, alpha polypeptide | PI3KC2 | PI3K-C2alpha | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | phosphatidylinositol-4-phosphate 3-kinase
Database Links Click here for help
Alphafold O00443 (Hs), Q61194 (Mm)
BRENDA 2.7.1.154
CATH/Gene3D 1.10.1070.11, 2.60.40.150, 3.30.1520.10
ChEMBL Target CHEMBL1075102 (Hs)
Ensembl Gene ENSG00000011405 (Hs), ENSMUSG00000030660 (Mm), ENSRNOG00000020479 (Rn)
Entrez Gene 5286 (Hs), 18704 (Mm), 361632 (Rn)
Human Protein Atlas ENSG00000011405 (Hs)
KEGG Enzyme 2.7.1.154
KEGG Gene hsa:5286 (Hs), mmu:18704 (Mm), rno:361632 (Rn)
OMIM 603601 (Hs)
Pharos O00443 (Hs)
RefSeq Nucleotide NM_002645 (Hs), NM_011083 (Mm), NM_001108500 (Rn)
RefSeq Protein NP_002636 (Hs), NP_035213 (Mm), NP_001101970 (Rn)
UniProtKB O00443 (Hs), Q61194 (Mm)
Wikipedia PIK3C2A (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated with ligand binding.
PDB Id:  2RED
Resolution:  2.1Å
Species:  Human
References:  2
Enzyme Reaction Click here for help
EC Number: 2.7.1.154

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
torin 2 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.6 pIC50 1
⤷ pIC50 7.6 (IC50 2.81x10-8 M) [1]
Immuno Process Associations
Immuno Process:  Antigen presentation

References

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1. Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Ahmed T, Sabatini DM, Gray NS. (2011) Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J Med Chem, 54 (5): 1473-80. [PMID:21322566]

2. Parkinson GN, Vines D, Driscoll PC, Djordjevic S. (2008) Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding. BMC Struct Biol, 8: 13. [PMID:18312637]

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