Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	343	Xq28	PNCK	pregnancy up-regulated nonubiquitous CaM kinase
Mouse	-	343	X 37.38 cM	Pnck	pregnancy upregulated non-ubiquitously expressed CaM kinase
Rat	-	343	Xq37	Pnck	pregnancy up-regulated nonubiquitous CaM kinase

Previous and Unofficial Names

Bstk3 | caM kinase IB | caM-KI beta | Punc | pregnancy up-regulated non-ubiquitously expressed CaM kinase

Database Links
Alphafold	Q6P2M8 (Hs), Q9QYK9 (Mm), O70150 (Rn)
BRENDA	2.7.11.17
ChEMBL Target	CHEMBL3627592 (Hs)
Ensembl Gene	ENSG00000130822 (Hs), ENSMUSG00000002012 (Mm), ENSRNOG00000058317 (Rn)
Entrez Gene	139728 (Hs), 93843 (Mm), 29660 (Rn)
Human Protein Atlas	ENSG00000130822 (Hs)
KEGG Enzyme	2.7.11.17
KEGG Gene	hsa:139728 (Hs), mmu:93843 (Mm), rno:29660 (Rn)
OMIM	300680 (Hs)
Pharos	Q6P2M8 (Hs)
RefSeq Nucleotide	NM_198452 (Hs), NM_001199351 (Mm), NM_017275 (Rn)
RefSeq Protein	NP_001034671 (Hs), NP_001186280 (Mm), NP_058971 (Rn)
UniProtKB	Q6P2M8 (Hs), Q9QYK9 (Mm), O70150 (Rn)
Wikipedia	PNCK (Hs)

Enzyme Reaction
EC Number: 2.7.11.17

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/CAMK1b
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM staurosporine Hs Inhibitor Inhibition 4.8 SB 218078 Hs Inhibitor Inhibition 50.5 K-252a Hs Inhibitor Inhibition 55.7 Syk inhibitor II Hs Inhibitor Inhibition 57.3 Syk inhibitor Hs Inhibitor Inhibition 58.1 SU11652 Hs Inhibitor Inhibition 70.5 PDK1/Akt/Flt dual pathway inhibitor Hs Inhibitor Inhibition 83.4 SU9516 Hs Inhibitor Inhibition 86.3 VEGF receptor 2 kinase inhibitor I Hs Inhibitor Inhibition 88.6 Cdk1/2 inhibitor III Hs Inhibitor Inhibition 89.1
Displaying the top 10 most potent ligands  View all ligands in screen »