TATA-box binding protein associated factor 1 | TAF1 family | IUPHAR/BPS Guide to PHARMACOLOGY

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TATA-box binding protein associated factor 1

Target not currently curated in GtoImmuPdb

Target id: 2231

Nomenclature: TATA-box binding protein associated factor 1

Abbreviated Name: TAF1

Family: TAF1 family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1895 Xq13.1 TAF1 TATA-box binding protein associated factor 1
Mouse - 1893 X D Taf1 TATA-box binding protein associated factor 1
Rat - 1893 X q31 Taf1 TATA-box binding protein associated factor 1
Previous and Unofficial Names
Ccg1 | dystonia 3 (with Parkinsonism) | DYT3/TAF1 | KAT4 | TAF2A, BA2R, CCG1, CCGS, DYT3 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF1 RNA polymerase II
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the tandem bromodomains of human transcription initiation factor TFIID subunit 1 (TAF1).
PDB Id:  3UV5
Resolution:  2.03Å
Species:  Human
References:  1
Enzyme Reaction
EC Number: 2.7.11.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
BAY-299 Hs Inhibition 7.9 pIC50 2
pIC50 7.9 (IC50 1.3x10-8 M) [2]
Description: In a BROMOscan® assay.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Dystonia 3, torsion, X-linked; DYT3
Synonyms: X-linked dystonia-parkinsonism [Orphanet: ORPHA53351]
OMIM: 314250
Orphanet: ORPHA53351
General Comments
TAF1 is a component of the STAGA complex, which contains TRRAP, GCN5, TFIID, CBP/P300 and Sp1. TAF1 is susceptible to oncogenic activation by MYC and has been shown to block p53 activity. Inactivation of TAF1 triggers a DNA damage response. BAY-299 is an inhibitor of TAF1 that can be used to further characterise its biological role and may also provide a lead for future development for anti-proliferative potential.

References

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1. Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T et al.. (2012) Histone recognition and large-scale structural analysis of the human bromodomain family. Cell, 149 (1): 214-31. [PMID:22464331]

2. SGC. BAY-299 A probe for BRD1 and TAF1. Accessed on 05/04/2017. Modified on 05/04/2017. SGC, http://www.thesgc.org/chemical-probes/BAY-299

How to cite this page

TAF1 family: TATA-box binding protein associated factor 1. Last modified on 05/04/2017. Accessed on 23/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2231.