Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1872	Xq13.1	TAF1	TATA-box binding protein associated factor 1
Mouse	-	1891	X 44.29 cM	Taf1	TATA-box binding protein associated factor 1
Rat	-	1893	X q31	Taf1	TATA-box binding protein associated factor 1

Previous and Unofficial Names

Ccg1 | dystonia 3 (with Parkinsonism) | DYT3/TAF1 | KAT4 | TAF2A, BA2R, CCG1, CCGS, DYT3 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF1 RNA polymerase II

Database Links
Alphafold	P21675 (Hs), Q80UV9 (Mm)
BRENDA	2.7.11.1
CATH/Gene3D	1.10.1100.10, 1.20.920.10
ChEMBL Target	CHEMBL3217390 (Hs)
Ensembl Gene	ENSG00000147133 (Hs), ENSMUSG00000031314 (Mm), ENSRNOG00000002565 (Rn)
Entrez Gene	6872 (Hs), 270627 (Mm), 317256 (Rn)
Human Protein Atlas	ENSG00000147133 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:6872 (Hs), mmu:270627 (Mm), rno:317256 (Rn)
OMIM	313650 (Hs)
Orphanet	ORPHA139199 (Hs)
Pharos	P21675 (Hs)
RefSeq Nucleotide	NM_001286074 (Hs), NM_001290729 (Mm), NM_001191723 (Rn)
RefSeq Protein	NP_001273003 (Hs), NP_001277658 (Mm), NP_001178652 (Rn)
UniProtKB	P21675 (Hs), Q80UV9 (Mm)
Wikipedia	TAF1 (Hs)

Selected 3D Structures
	Description:  Crystal structure of the tandem bromodomains of human transcription initiation factor TFIID subunit 1 (TAF1). PDB Id:  3UV5 Resolution:  2.03Å Species:  Human References:  1

Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference BAY-299 Hs Inhibition 7.9 pIC50 2 ⤷ pIC50 7.9 (IC50 1.3x10-8 M) [2] Description: In a BROMOscan® assay.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Dystonia 3, torsion, X-linked; DYT3 Synonyms: X-linked dystonia-parkinsonism [Orphanet: ORPHA53351] OMIM: 314250 Orphanet: ORPHA53351

General Comments

TAF1 is a component of the STAGA complex, which contains TRRAP, GCN5, TFIID, CBP/P300 and Sp1. TAF1 is susceptible to oncogenic activation by MYC and has been shown to block p53 activity. Inactivation of TAF1 triggers a DNA damage response. BAY-299 is an inhibitor of TAF1 that can be used to further characterise its biological role and may also provide a lead for future development for anti-proliferative potential.