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Granulocyte macrophage colony-stimulating factor receptor

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2309

Nomenclature: Granulocyte macrophage colony-stimulating factor receptor

Family: IL-3 receptor family

Quaternary Structure: Subunits
GM-CSF receptor, α subunit (Ligand-binding subunit)
Cytokine receptor common β subunit (Other subunit)
Previous and Unofficial Names Click here for help
GM-CSF receptor
Natural/Endogenous Ligands Click here for help
G-CSF {Sp: Human}
GM-CSF {Sp: Human}

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Agonists
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Ligand Sp. Action Value Parameter Reference
G-CSF {Sp: Human} Peptide Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
GM-CSF {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
Immunopharmacology Comments
The functional GM-CSF receptor is a heterodimer consisting of the ligand binding GM-CSF receptor α subunit (CSF2RA) and CSF2RB (cytokine receptor common β subunit). CSF2RB is required for the formation of the functional receptors for IL-3, IL-5 and GM-CSF.

How to cite this page

IL-3 receptor family: Granulocyte macrophage colony-stimulating factor receptor. Last modified on 22/03/2017. Accessed on 11/05/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2309.