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| Quaternary Structure: Subunits |
| Interleukin 27 receptor, alpha (Ligand-binding subunit) |
| Interleukin-6 receptor, β subunit (Other subunit) |
Natural/Endogenous Ligands  |
| IL-27 {Sp: Human} |
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| Immunopharmacology Comments |
| The functional IL-27 receptor is a heterodimer of the ligand binding IL-27 receptor α subunit (IL27RA) and the IL-6 receptor signal transducing subunit (IL6ST) [2]. IL-27 receptor acts via the Th1 cell-specific transcription factor T-bet (TBX21) to control expression of interferon γ, and Th1 commitment [1]. |
1. Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature, 407 (6806): 916-20. [PMID:11057672]
2. Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA. (2004) WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol, 172 (4): 2225-31. [PMID:14764690]
IL-6 receptor family: Interleukin-27 receptor. Last modified on 07/04/2017. Accessed on 08/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2316.
target has curated data in GtoImmuPdb
