BRCA1 associated protein 1 | C12: Ubiquitin C-terminal hydrolase | IUPHAR/BPS Guide to PHARMACOLOGY

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BRCA1 associated protein 1

Target not currently curated in GtoImmuPdb

Target id: 2332

Nomenclature: BRCA1 associated protein 1

Family: C12: Ubiquitin C-terminal hydrolase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 729 3p21.31-p21.2 BAP1 BRCA1 associated protein 1
Mouse - 728 14 B Bap1 Brca1 associated protein 1
Rat - 727 16p16 Bap1 Brca1 associated protein 1
Previous and Unofficial Names
ubiquitin C-terminal hydrolase X4 | UCHL2 | uch-x4 | hucep-6 | BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Database Links
Specialist databases
MEROPS C12.004 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.19.12
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0050727 regulation of inflammatory response IMP
click arrow to show/hide IEA associations
GO:1900015 regulation of cytokine production involved in inflammatory response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes, IEA only
GO:0050727 regulation of inflammatory response IMP
click arrow to show/hide IEA associations
GO:0061519 macrophage homeostasis IEA
GO:1900015 regulation of cytokine production involved in inflammatory response IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:1900015 regulation of cytokine production involved in inflammatory response IEA
Clinically-Relevant Mutations and Pathophysiology
Disease:  Malignant mesothelioma
Disease Ontology: DOID:1790
OMIM: 156240
Disease:  Tumor predisposition syndrome
Synonyms: BAP1-related tumor predisposition syndrome [Orphanet: ORPHA289539]
OMIM: 614327
Orphanet: ORPHA289539

How to cite this page

C12: Ubiquitin C-terminal hydrolase: BRCA1 associated protein 1. Last modified on 29/01/2016. Accessed on 10/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2332.