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fibroblast activation protein alpha

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Target not currently curated in GtoImmuPdb

Target id: 2365

Nomenclature: fibroblast activation protein alpha

Family: S9: Prolyl oligopeptidase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 760 2q24.2 FAP fibroblast activation protein alpha
Mouse 1 761 2 35.85 cM Fap fibroblast activation protein
Rat - 761 3q21 Fap fibroblast activation protein, alpha
Previous and Unofficial Names Click here for help
DPPIV | seprase
Database Links Click here for help
Specialist databases
MEROPS S09.007 (Hs)
Other databases
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 9 [PMID: 20718420] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 7.7 pIC50 2
pIC50 7.7 (IC50 1.9x10-8 M) [2]
ARI-3099 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 7.4 pIC50 1
pIC50 7.4 (IC50 3.6x10-8 M) [1]

References

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1. Poplawski SE, Lai JH, Li Y, Jin Z, Liu Y, Wu W, Wu Y, Zhou Y, Sudmeier JL, Sanford DG et al.. (2013) Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem, 56 (9): 3467-77. [PMID:23594271]

2. Tsai TY, Yeh TK, Chen X, Hsu T, Jao YC, Huang CH, Song JS, Huang YC, Chien CH, Chiu JH et al.. (2010) Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein. J Med Chem, 53 (18): 6572-83. [PMID:20718420]

How to cite this page

S9: Prolyl oligopeptidase: fibroblast activation protein alpha. Last modified on 09/04/2018. Accessed on 23/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2365.