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Gene and Protein Information  |
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| Frizzled family G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 591 | 7q11.23 | FZD9 | frizzled class receptor 9 | |
| Mouse | 7 | 592 | 5 75.08 cM | Fzd9 | frizzled class receptor 9 | |
| Rat | 7 | 592 | 12q12 | Fzd9 | frizzled class receptor 9 | |
| Previous and Unofficial Names |
| CD349 | FZD3 | frizzled family receptor 9 | FZD9 |
| Database Links |
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| Alphafold | O00144 (Hs), Q9R216 (Mm), Q8K4C8 (Rn) |
| CATH/Gene3D | 1.10.2000.10 |
| ChEMBL Target | CHEMBL4523116 (Hs) |
| Ensembl Gene | ENSG00000188763 (Hs), ENSMUSG00000049551 (Mm), ENSRNOG00000001452 (Rn) |
| Entrez Gene | 8326 (Hs), 14371 (Mm), 266608 (Rn) |
| Human Protein Atlas | ENSG00000188763 (Hs) |
| KEGG Gene | hsa:8326 (Hs), mmu:14371 (Mm), rno:266608 (Rn) |
| OMIM | 601766 (Hs) |
| Pharos | O00144 (Hs) |
| RefSeq Nucleotide | NM_003508 (Hs), NM_010246 (Mm), NM_153305 (Rn) |
| RefSeq Protein | NP_003499 (Hs), NP_034376 (Mm), NP_695217 (Rn) |
| UniProtKB | O00144 (Hs), Q9R216 (Mm), Q8K4C8 (Rn) |
| Wikipedia | FZD9 (Hs) |
| Natural/Endogenous Ligands |
| Wnt |
| Agonist Comments | ||
| Wnt-2 activates FZD9-dependent TCF transcription [4]. Wnt-7a interacts with FZD9 and activates the JNK pathway [9]. |
| Secondary Transduction Mechanisms |
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| Transducer | Effector/Response |
| Gi/Go family | |
| References: 5 | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| Physiological Functions
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| Physiological Consequences of Altering Gene Expression
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Clinically-Relevant Mutations and Pathophysiology Comments |
| FZD9 is located in 7q11.23, the same locus, where the deletion causing Williams syndrome occurs [7]. |
1. Albers J, Schulze J, Beil FT, Gebauer M, Baranowsky A, Keller J, Marshall RP, Wintges K, Friedrich FW, Priemel M et al.. (2011) Control of bone formation by the serpentine receptor Frizzled-9. J Cell Biol, 192 (6): 1057-72. [PMID:21402791]
2. Fujimoto T, Tomizawa M, Yokosuka O. (2009) SiRNA of frizzled-9 suppresses proliferation and motility of hepatoma cells. Int J Oncol, 35 (4): 861-6. [PMID:19724923]
3. Jiang Y, Dunbar A, Gondek LP, Mohan S, Rataul M, O'Keefe C, Sekeres M, Saunthararajah Y, Maciejewski JP. (2009) Aberrant DNA methylation is a dominant mechanism in MDS progression to AML. Blood, 113 (6): 1315-25. [PMID:18832655]
4. Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ. (2002) Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling. J Biol Chem, 277 (40): 37479-86. [PMID:12138115]
5. Ramírez VT, Ramos-Fernández E, Henríquez JP, Lorenzo A, Inestrosa NC. (2016) Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation. J Biol Chem, 291 (36): 19092-107. [PMID:27402827]
6. Ranheim EA, Kwan HC, Reya T, Wang YK, Weissman IL, Francke U. (2005) Frizzled 9 knock-out mice have abnormal B-cell development. Blood, 105 (6): 2487-94. [PMID:15572594]
7. Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U. (1997) A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23. Hum Mol Genet, 6 (3): 465-72. [PMID:9147651]
8. Wang YK, Spörle R, Paperna T, Schughart K, Francke U. (1999) Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. Genomics, 57 (2): 235-48. [PMID:10198163]
9. Winn RA, Marek L, Han SY, Rodriguez K, Rodriguez N, Hammond M, Van Scoyk M, Acosta H, Mirus J, Barry N et al.. (2005) Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. J Biol Chem, 280 (20): 19625-34. [PMID:15705594]
10. Zhao C, Avilés C, Abel RA, Almli CR, McQuillen P, Pleasure SJ. (2005) Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval. Development, 132 (12): 2917-27. [PMID:15930120]
11. Zhao C, Pleasure SJ. (2005) Frizzled9 protein is regionally expressed in the developing medial cortical wall and the cells derived from this region. Brain Res Dev Brain Res, 157 (1): 93-7. [PMID:15939089]
