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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 254 | 19q13.41 | KLK4 | kallikrein related peptidase 4 | |
Mouse | - | 255 | 7 B4 | Klk4 | kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) | |
Rat | - | 256 | 1q22 | Klk4 | kallikrein-related peptidase 4 |
Previous and Unofficial Names ![]() |
EMSP | ESMP1 | kallikrein 4 | KLK-L1 | Prss17 | PSTS | kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) | kallikrein related-peptidase 4 (prostase |
Database Links ![]() |
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Specialist databases | |
MEROPS | S01.251 (Hs) |
Other databases | |
Alphafold | Q9Y5K2 (Hs) |
BRENDA | 3.4.21.- |
ChEMBL Target | CHEMBL4446 (Hs) |
Ensembl Gene | ENSG00000167749 (Hs), ENSMUSG00000006948 (Mm), ENSRNOG00000018864 (Rn) |
Entrez Gene | 9622 (Hs), 56640 (Mm), 408210 (Rn) |
Human Protein Atlas | ENSG00000167749 (Hs) |
KEGG Enzyme | 3.4.21.- |
KEGG Gene | hsa:9622 (Hs), mmu:56640 (Mm), rno:408210 (Rn) |
OMIM | 603767 (Hs) |
Orphanet | ORPHA139168 (Hs) |
Pharos | Q9Y5K2 (Hs) |
RefSeq Nucleotide | NM_004917 (Hs), NM_019928 (Mm), NM_001004101 (Rn) |
RefSeq Protein | NP_004908 (Hs), NP_064312 (Mm), NP_001004101 (Rn) |
UniProtKB | Q9Y5K2 (Hs) |
Wikipedia | KLK4 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. De Vita E, Smits N, van den Hurk H, Beck EM, Hewitt J, Baillie G, Russell E, Pannifer A, Hamon V, Morrison A et al.. (2020) Synthesis and Structure-Activity Relationships of N-(4-Benzamidino)-Oxazolidinones: Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6. ChemMedChem, 15 (1): 79-95. [PMID:31675166]
2. Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR et al.. (2010) Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem, 53 (1): 52-60. [PMID:19908842]
S1: Chymotrypsin: kallikrein related peptidase 4. Last modified on 06/12/2019. Accessed on 08/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2374.