Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	433	14q32.12	LGMN	legumain
Mouse	-	435	12 E	Lgmn	legumain
Rat	-	435	6q32	Lgmn	legumain

Previous and Unofficial Names

AEP1 | asparagine endo peptidase | asparagine endopeptidase | asparaginyl endopeptidase 1 | LGMN1 | protease, cysteine 1 | Prsc1

Database Links
Specialist databases
MEROPS	C13.004 (Hs)
Other databases
Alphafold	Q99538 (Hs), O89017 (Mm), Q9R0J8 (Rn)
BRENDA	3.4.22.34
ChEMBL Target	CHEMBL4244 (Hs), CHEMBL1949492 (Mm)
Ensembl Gene	ENSG00000100600 (Hs), ENSMUSG00000021190 (Mm), ENSRNOG00000007089 (Rn)
Entrez Gene	5641 (Hs), 19141 (Mm), 63865 (Rn)
Human Protein Atlas	ENSG00000100600 (Hs)
KEGG Enzyme	3.4.22.34
KEGG Gene	hsa:5641 (Hs), mmu:19141 (Mm), rno:63865 (Rn)
OMIM	602620 (Hs)
Pharos	Q99538 (Hs)
RefSeq Nucleotide	NM_005606 (Hs), NM_001008530 (Hs), NM_011175 (Mm), NM_022226 (Rn)
RefSeq Protein	NP_001008530 (Hs), NP_005597 (Hs), NP_035305 (Mm), NP_071562 (Rn)
UniProtKB	Q99538 (Hs), O89017 (Mm), Q9R0J8 (Rn)
Wikipedia	LGMN (Hs)

Enzyme Reaction
EC Number: 3.4.22.34

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 7u [PMID: 24775305] Hs Inhibition 9.1 pIC50 1 ⤷ pIC50 9.1 (IC50 9x10-10 M) [1] compound 18 [PMID: 38090813] Hs Inhibition 8.1 pIC50 2 ⤷ pIC50 8.1 (IC50 7.8x10-9 M) [2]

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Antigen presentation

Immuno Process:  Cellular signalling

Immuno Process:  Immune regulation

Immuno Process:  Chemotaxis & migration