Top ▲

proprotein convertase subtilisin/kexin type 7

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2387

Nomenclature: proprotein convertase subtilisin/kexin type 7

Family: S8: Subtilisin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 785 11q23.3 PCSK7 proprotein convertase subtilisin/kexin type 7
Mouse 1 770 9 25.32 cM Pcsk7 proprotein convertase subtilisin/kexin type 7
Rat 1 783 8q22 Pcsk7 proprotein convertase subtilisin/kexin type 7
Previous and Unofficial Names Click here for help
PC8 | SPC7 | LPC | prohormone convertase 7 | prohormone convertase PC7
Database Links Click here for help
Specialist databases
MEROPS S08.077 (Hs)
Other databases
Alphafold Q16549 (Hs), Q61139 (Mm), Q62849 (Rn)
BRENDA 3.4.21.-
CATH/Gene3D 2.60.120.260, 3.40.50.200
ChEMBL Target CHEMBL2232 (Hs)
Ensembl Gene ENSG00000160613 (Hs), ENSMUSG00000035382 (Mm), ENSRNOG00000017478 (Rn)
Entrez Gene 9159 (Hs), 18554 (Mm), 29606 (Rn)
Human Protein Atlas ENSG00000160613 (Hs)
KEGG Enzyme 3.4.21.-
KEGG Gene hsa:9159 (Hs), mmu:18554 (Mm), rno:29606 (Rn)
OMIM 604872 (Hs)
Pharos Q16549 (Hs)
RefSeq Nucleotide NM_004716 (Hs), NM_008794 (Mm), NM_019246 (Rn)
RefSeq Protein NP_004707 (Hs), NP_032820 (Mm), NP_062119 (Rn)
UniProtKB Q16549 (Hs), Q61139 (Mm), Q62849 (Rn)
Wikipedia PCSK7 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
peptide 18 [PMID: 24350995] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.9 pKi 1
⤷ pKi 7.9 (Ki 1.38x10-8 M) [1]
furin inhibitor peptide Peptide Click here for species-specific activity table Hs Inhibition 6.8 pKi 2
⤷ pKi 6.8 (Ki 1.52x10-7 M) [2]

References

Show »

1. Kwiatkowska A, Couture F, Levesque C, Ly K, Desjardins R, Beauchemin S, Prahl A, Lammek B, Neugebauer W, Dory YL et al.. (2014) Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem, 57 (1): 98-109. [PMID:24350995]

2. Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R et al.. (2007) Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem, 282 (29): 20847-53. [PMID:17537721]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 7. Last modified on 28/07/2015. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2387.