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serine protease 8

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Target not currently curated in GtoImmuPdb

Target id: 2400

Nomenclature: serine protease 8

Family: S1: Chymotrypsin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 343 16p11.2 PRSS8 serine protease 8
Mouse 1 342 7 69.84 cM Prss8 serine protease 8 (prostasin)
Rat 1 342 1q37 Prss8 serine protease 8
Previous and Unofficial Names Click here for help
CAP1 | channel activating protease 1 | prostasin | protease | protease, serine 8 | protease, serine, 8 (prostasin) | protease, serine 8 (prostasin)
Database Links Click here for help
Specialist databases
MEROPS S01.159 (Hs)
Other databases
Alphafold Q16651 (Hs), Q9ESD1 (Mm), Q9ES87 (Rn)
BRENDA 3.4.21.-
ChEMBL Target CHEMBL5610 (Hs)
Ensembl Gene ENSG00000052344 (Hs), ENSMUSG00000030800 (Mm), ENSRNOG00000019616 (Rn)
Entrez Gene 5652 (Hs), 76560 (Mm), 192107 (Rn)
Human Protein Atlas ENSG00000052344 (Hs)
KEGG Enzyme 3.4.21.-
KEGG Gene hsa:5652 (Hs), mmu:76560 (Mm), rno:192107 (Rn)
OMIM 600823 (Hs)
Pharos Q16651 (Hs)
RefSeq Nucleotide NM_002773 (Hs), NM_133351 (Mm), NM_138836 (Rn)
RefSeq Protein NP_002764 (Hs), NP_579929 (Mm), NP_620191 (Rn)
UniProtKB Q16651 (Hs), Q9ESD1 (Mm), Q9ES87 (Rn)
Wikipedia PRSS8 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
B3C Small molecule or natural product Primary target of this compound Hs Inhibition 7.9 pKi 1
⤷ pKi 7.9 (Ki 1.2x10-8 M) [1]

References

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1. Tully DC, Vidal A, Chatterjee AK, Williams JA, Roberts MJ, Petrassi HM, Spraggon G, Bursulaya B, Pacoma R, Shipway A et al.. (2008) Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorg Med Chem Lett, 18 (22): 5895-9. [PMID:18752942]

How to cite this page

S1: Chymotrypsin: serine protease 8. Last modified on 27/02/2018. Accessed on 04/11/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2400.