Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	343	16p11.2	PRSS8	serine protease 8
Mouse	1	342	7 69.84 cM	Prss8	serine protease 8 (prostasin)
Rat	1	342	1q37	Prss8	serine protease 8

Previous and Unofficial Names

CAP1 | channel activating protease 1 | prostasin | protease | protease, serine 8 | protease, serine, 8 (prostasin) | protease, serine 8 (prostasin)

Database Links
Specialist databases
MEROPS	S01.159 (Hs)
Other databases
Alphafold	Q16651 (Hs), Q9ESD1 (Mm), Q9ES87 (Rn)
BRENDA	3.4.21.-
ChEMBL Target	CHEMBL5610 (Hs)
Ensembl Gene	ENSG00000052344 (Hs), ENSMUSG00000030800 (Mm), ENSRNOG00000019616 (Rn)
Entrez Gene	5652 (Hs), 76560 (Mm), 192107 (Rn)
Human Protein Atlas	ENSG00000052344 (Hs)
KEGG Enzyme	3.4.21.-
KEGG Gene	hsa:5652 (Hs), mmu:76560 (Mm), rno:192107 (Rn)
OMIM	600823 (Hs)
Pharos	Q16651 (Hs)
RefSeq Nucleotide	NM_002773 (Hs), NM_133351 (Mm), NM_138836 (Rn)
RefSeq Protein	NP_002764 (Hs), NP_579929 (Mm), NP_620191 (Rn)
UniProtKB	Q16651 (Hs), Q9ESD1 (Mm), Q9ES87 (Rn)
Wikipedia	PRSS8 (Hs)

Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference B3C Hs Inhibition 7.9 pKi 1 ⤷ pKi 7.9 (Ki 1.2x10-8 M) [1]