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proteasome 20S subunit beta 9

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Target not currently curated in GtoImmuPdb

Target id: 2409

Nomenclature: proteasome 20S subunit beta 9

Family: T1: Proteasome

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 219 6p21.32 PSMB9 proteasome 20S subunit beta 9
Mouse - 219 17 17.98 cM Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
Rat - 219 20p12 Psmb9 proteasome 20S subunit beta 9
Previous and Unofficial Names Click here for help
large multifunctional protease 2 | Lmp2 | low molecular mass protein 2 | macropain chain 7 | multicatalytic endopeptidase complex chain 7 | proteasome chain 7 | proteosome beta 9 subunit | RING12 | proteasome (prosome, macropain) subunit, beta type, 9 | proteasome (prosome | proteasome subunit beta 9
Database Links Click here for help
Specialist databases
MEROPS T01.013 (Hs)
Other databases
Alphafold P28065 (Hs), P28076 (Mm), P28077 (Rn)
BRENDA 3.4.25.1
CATH/Gene3D 3.60.20.10
ChEMBL Target CHEMBL1944495 (Hs), CHEMBL1944491 (Mm)
DrugBank Target P28065 (Hs)
Ensembl Gene ENSG00000240065 (Hs), ENSMUSG00000096727 (Mm), ENSRNOG00000000459 (Rn)
Entrez Gene 5698 (Hs), 16912 (Mm), 24967 (Rn)
Human Protein Atlas ENSG00000240065 (Hs)
KEGG Enzyme 3.4.25.1
KEGG Gene hsa:5698 (Hs), mmu:16912 (Mm), rno:24967 (Rn)
OMIM 177045 (Hs)
Pharos P28065 (Hs)
RefSeq Nucleotide NM_002800 (Hs), NM_013585 (Mm), NM_012708 (Rn)
RefSeq Protein NP_002791 (Hs), NP_038613 (Mm), NP_036840 (Rn)
UniProtKB P28065 (Hs), P28076 (Mm), P28077 (Rn)
Wikipedia PSMB9 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.25.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
zetomipzomib Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.9 pIC50 1
⤷ pIC50 6.9 (IC50 1.31x10-7 M) [1]
Description: Inhibition of proteolytic activity measured in MOLT-4 (human T cell leukemia) cell lysate using the ProCISE ELISA.
zetomipzomib Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Mm Inhibition 6.8 pIC50 1
⤷ pIC50 6.8 (IC50 1.79x10-7 M) [1]
Description: Inhibition of proteolytic activity measured in A20 (mouse B-cell lymphoma) cell lysate using the ProCISE ELISA.
View species-specific inhibitor tables
Immuno Process Associations
Immuno Process:  Antigen presentation
Immuno Process:  Cellular signalling
Immuno Process:  Cytokine production & signalling
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Inflammation

References

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1. Johnson HWB, Lowe E, Anderl JL, Fan A, Muchamuel T, Bowers S, Moebius DC, Kirk C, McMinn DL. (2018) Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide). J Med Chem, 61 (24): 11127-11143. [PMID:30380863]

How to cite this page

T1: Proteasome: proteasome 20S subunit beta 9. Last modified on 12/09/2019. Accessed on 04/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2409.