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proteasome 20S subunit beta 9

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Target not currently curated in GtoImmuPdb

Target id: 2409

Nomenclature: proteasome 20S subunit beta 9

Family: T1: Proteasome

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 219 6p21.32 PSMB9 proteasome 20S subunit beta 9
Mouse - 219 17 17.98 cM Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
Rat - 219 20p12 Psmb9 proteasome 20S subunit beta 9
Previous and Unofficial Names Click here for help
large multifunctional protease 2 | Lmp2 | low molecular mass protein 2 | macropain chain 7 | multicatalytic endopeptidase complex chain 7 | proteasome chain 7 | proteosome beta 9 subunit | RING12 | proteasome (prosome, macropain) subunit, beta type, 9 | proteasome (prosome | proteasome subunit beta 9
Database Links Click here for help
Specialist databases
MEROPS T01.013 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.25.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
KZR-616 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.9 pIC50 1
pIC50 6.9 (IC50 1.31x10-7 M) [1]
Description: Inhibition of proteolytic activity measured in MOLT-4 (human T cell leukemia) cell lysate using the ProCISE ELISA.
KZR-616 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Mm Inhibition 6.8 pIC50 1
pIC50 6.8 (IC50 1.79x10-7 M) [1]
Description: Inhibition of proteolytic activity measured in A20 (mouse B-cell lymphoma) cell lysate using the ProCISE ELISA.
View species-specific inhibitor tables
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 2 GO processes
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
GO:0019882 antigen processing and presentation IDA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0000209 protein polyubiquitination TAS
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0050852 T cell receptor signaling pathway TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
GO:0070498 interleukin-1-mediated signaling pathway TAS
GO:0071347 cellular response to interleukin-1 IEP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0050852 T cell receptor signaling pathway TAS
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes
GO:0048536 spleen development IEP
GO:0048538 thymus development IEP
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS

References

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1. Johnson HWB, Lowe E, Anderl JL, Fan A, Muchamuel T, Bowers S, Moebius DC, Kirk C, McMinn DL. (2018) Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide). J Med Chem, 61 (24): 11127-11143. [PMID:30380863]

How to cite this page

T1: Proteasome: proteasome 20S subunit beta 9. Last modified on 12/09/2019. Accessed on 15/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2409.