Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	406	1q32.1	REN	renin
Mouse	-	402	1 57.91 cM	Ren1	renin 1 structural
Rat	-	402	13q13	Ren	renin

Previous and Unofficial Names

angiotensinogenase | aspartyl-protease | kidney renin | Ren1 | Ren-A | RENAA | renin b | Rnr

Database Links
Specialist databases
MEROPS	A01.007 (Hs)
Other databases
Alphafold	P00797 (Hs), P06281 (Mm), P08424 (Rn)
BRENDA	3.4.23.15
CATH/Gene3D	2.40.70.10
ChEMBL Target	CHEMBL286 (Hs), CHEMBL2615 (Mm), CHEMBL2322 (Rn)
DrugBank Target	P00797 (Hs)
Ensembl Gene	ENSG00000143839 (Hs), ENSMUSG00000070645 (Mm), ENSRNOG00000002937 (Rn)
Entrez Gene	5972 (Hs), 19701 (Mm), 24715 (Rn)
Human Protein Atlas	ENSG00000143839 (Hs)
KEGG Enzyme	3.4.23.15
KEGG Gene	hsa:5972 (Hs), mmu:19701 (Mm), rno:24715 (Rn)
OMIM	179820 (Hs)
Orphanet	ORPHA138530 (Hs)
Pharos	P00797 (Hs)
RefSeq Nucleotide	NM_000537 (Hs), NM_031192 (Mm), NM_012642 (Rn)
RefSeq Protein	NP_000528 (Hs), NP_112469 (Mm), NP_036774 (Rn)
SynPHARM	78508 (in complex with aliskiren)
UniProtKB	P00797 (Hs), P06281 (Mm), P08424 (Rn)
Wikipedia	REN (Hs)

Enzyme Reaction
EC Number: 3.4.23.15

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference sitokiren Hs Inhibition 9.4 pIC50 1 ⤷ pIC50 9.4 (IC50 4x10-10 M) [1] Description: Inhibition of recombinant human renin in vitro aliskiren Hs Inhibition 9.2 pIC50 2 ⤷ pIC50 9.2 (IC50 6x10-10 M) [2]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Hyperuricemic nephropathy, familial juvenile 2; HNFJ2 Synonyms: Familial juvenile hyperuricemic nephropathy [Disease Ontology: DOID:0060062] Hyperuricemia - anemia - renal failure [Orphanet: ORPHA217330] Disease Ontology: DOID:0060062 OMIM: 613092 Orphanet: ORPHA217330
Disease:  Renal tubular dysgenesis OMIM: 267430 Orphanet: ORPHA97369

General Comments
Cleaves the precursor angiotensinogen to generate angiotensin I.